Conformational dynamics of the most efficient carboxylase contributes to efficient CO2 fixation [PDF]
, 2023 Crotonyl-CoA carboxylase/reductase (Ccr) is one of the fastest CO2 fixing enzymes and has become part of efficient artificial CO2-fixation pathways in vitro, paving the way for future applications.
Helmut, Grubmüller +3 more
core +2 more sources
Intrinsic determinants of prion protein neurotoxicity in Drosophila: from sequence to (dys)function
Frontiers in Molecular Neuroscience, 2023 Prion diseases are fatal brain disorders characterized by deposition of insoluble isoforms of the prion protein (PrP). The normal and pathogenic structures of PrP are relatively well known after decades of studies.
Alessandro Cembran +1 more
doaj +1 more source
The Onset of Molecule‐Spanning Dynamics in Heat Shock Protein Hsp90
Advanced Science, 2023 Protein dynamics have been investigated on a wide range of time scales. Nano‐ and picosecond dynamics have been assigned to local fluctuations, while slower dynamics have been attributed to larger conformational changes.
Benedikt Sohmen +11 more
doaj +1 more source
Conformational Dynamics of RNA G4C2 and C2G4 Repeat Expansions causing ALS/FTD using NMR and Molecular Dynamics Studies [PDF]
, 2023 RNA G4C2 and C4G2 repeat expansions in the chromosome 9 open reading frame 72 gene (C9orf72) are the most common cause of genetically defined amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), referred to as c9ALS/FTD.
Jessica, Childs-Disney +4 more
core +1 more source
Characterisation of HOIP RBR E3 ligase conformational dynamics using integrative modelling
Scientific Reports, 2022 Multidomain proteins composed of individual domains connected by flexible linkers pose a challenge for structural studies due to their intrinsic conformational dynamics.
Marius Kausas +3 more
doaj +1 more source
Opinion Dynamics Under Conformity [PDF]
SSRN Electronic Journal, 2012 We present a model of opinion formation where individuals repeatedly engage in discussion and update their opinion in a social network similarly to the DeGroot model. Abstracting from the standard assumption that individuals always report their opinion truthfully, agents in our model interact strategically in the discussion such that their stated ...
Buechel, Berno +2 more
openaire +2 more sources
Conformational flexibility influences structure–function relationships in tyrosyl protein sulfotransferase-2 [PDF]
, 2016 Tyrosine sulfation is a very important posttranslational modification of proteins. It is catalyzed by tyrosylprotein sulfotransferase and recently became increasingly important for biomedicine and pharmacy.
Karabencheva-Christova, T. G. +8 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Conformational dynamics of STIM1 activation [PDF]
Nature Structural & Molecular Biology, 2013 The binding of stromal interaction molecule 1 (STIM1) to ORAI calcium channels is critical for store-operated calcium entry (SOCE), a calcium influx pathway conserved among nearly all vertebrate cells. Although many major steps of this pathway are well understood, crucial details regarding the mechanism of STIM1 activation remain unclear.
Stefan, Feske, Murali, Prakriya
openaire +2 more sources
Exploring conformational dynamics of flavoenzymes with flavin fluorescence relaxation spectroscopy [PDF]
, 2002 Research described in this thesis was aimed at gaining more insight into the active-site dynamics of dimeric flavoproteins by means of fluorescence relaxation spectroscopy.
Berg, P.A.W., van den +1 more
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