Results 21 to 30 of about 3,454,137 (301)
Pressure, motion, and conformational entropy in molecular recognition by proteins
Biophysical Reports, 2023 The thermodynamics of molecular recognition by proteins is a central determinant of complex biochemistry. For over a half-century, detailed cryogenic structures have provided deep insight into the energetic contributions to ligand binding by proteins ...
José A. Caro +3 more
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Molecular dynamics as an approach to study prion protein misfolding and the effect of pathogenic mutations [PDF]
, 2011 Computer simulation of protein dynamics offers unique high-resolution information that complements experiment. Using experimentally derived structures of the natively folded prion protein (PrP), physically realistic dynamics and conformational changes ...
Valerie Daggett +3 more
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On the dynamics of molecular conformation [PDF]
Proceedings of the National Academy of Sciences, 2006 Understanding the mechanism of fast transitions between conformed states of large biomolecules is central to reconciling the dichotomy between the relatively high speed of metabolic processes and slow (random-walk based) estimates on the speed of biomolecular processes.
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Fluorescence-based methods to study rapid dynamics and conformational flexibility in peptides [PDF]
, 2004 Intramolecular collision of polypeptides is the primary step in protein folding, the dynamics of which is of importance for understanding this fascinating topic.
Huang, Fang
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PLoS ONE, 2012 Exchange proteins directly activated by cAMP (EPACs) are important allosteric regulators of cAMP-mediated signal transduction pathways. To understand the molecular mechanism of EPAC activation, we have combined site-directed mutagenesis, X-ray ...
Mark A White +6 more
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The dynamic landscape of transcription initiation in yeast mitochondria
Nature Communications, 2020 Conformational dynamics during the early stage of transcription is crucial to understanding the regulation of transcription efficiency and fidelity.
Byeong-Kwon Sohn +9 more
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Conformational dynamics of vesicles [PDF]
Proceedings of the National Academy of Sciences, 1999 The transport of ions and molecules through membranes is a key ingredient to many biophysical processes. For example, contemporary attempts for gene therapy require transport of DNA fragments through the cellular and nuclear membranes (1); signaling depends on ionic transport through dynamic pores in membranes (see, for example, ref. 2); efficient drug
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Conformational dynamics, ligand binding and effects of mutations in NirE an S-adenosyl-L-methionine dependent Methyltransferase [PDF]
, 2016 Heme d1, a vital tetrapyrrol involved in the denitrification processes is synthesized from its precursor molecule precorrin-2 in a chemical reaction catalysed by an S-adenosyl-L-methionine (SAM) dependent Methyltransferase (NirE).
Singh, Warispreet +5 more
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Random Conformal Dynamical Systems [PDF]
Geometric and Functional Analysis, 2007 We consider random dynamical systems such as groups of conformal transformations with a probability measure, or transversaly conformal foliations with a Laplace operator along the leaves, in which case we consider the holonomy pseudo-group. We prove that either there exists a measure invariant under all the elements of the group (or the pseudo-group ...
Deroin, Bertrand, Kleptsyn, Victor A.
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How does conformational flexibility influence key structural features involved in activation of anaplastic lymphoma kinase? [PDF]
, 2014 Anaplastic Lymphoma Kinase (ALK) plays a major role in developing tumor processes and therefore has emerged as a validated therapeutic target. Applying atomistic molecular dynamics simulations on the wild type enzyme and the nine most frequently ...
Lee, Christian +4 more
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