Conformational flexibility influences structure–function relationships in tyrosyl protein sulfotransferase-2 [PDF]
, 2016 Tyrosine sulfation is a very important posttranslational modification of proteins. It is catalyzed by tyrosylprotein sulfotransferase and recently became increasingly important for biomedicine and pharmacy.
Karabencheva-Christova, T. G. +8 more
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Protein dynamics and conformational selection in bidirectional signal transduction
BMC Biology, 2012 Protein conformational dynamics simultaneously allow promiscuity and specificity in binding. The multiple conformations of the free EphA4 ligand-binding domain observed in two new EphA4 crystal structures provide a unique insight into the conformational ...
Nussinov Ruth, Ma Buyong
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Molecular dynamics simulation study of the binding of purine bases to the aptamer domain of the guanine sensing riboswitch [PDF]
, 2009 Riboswitches are a novel class of genetic control elements that function through the direct interaction of small metabolite molecules with structured RNA elements.
Stock, Gerhard +4 more
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ABCE1 Controls Ribosome Recycling by an Asymmetric Dynamic Conformational Equilibrium
Cell Reports, 2019 Summary: The twin-ATPase ABCE1 has a vital function in mRNA translation by recycling terminated or stalled ribosomes. As for other functionally distinct ATP-binding cassette (ABC) proteins, the mechanochemical coupling of ATP hydrolysis to conformational
Giorgos Gouridis +7 more
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Medicine in Novel Technology and Devices, 2019 The functions and activities of proteins are closely related to their structures and dynamics, and their interactions with ligands. Knowledge of the mechanistic events of proteins’ conformational transitions and interactions with ligands is crucially ...
Dechang Li, Baohua Ji
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Laboratory evolution of protein conformational dynamics
, 2018 This review focuses on recent work that has begun to establish specific functional roles for protein conformational dynamics, specifically how the conformational landscapes that proteins can sample can evolve under laboratory based evolutionary selection.
Nobuhiko Tokuriki +17 more
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Mapping the conformational energy landscape of Abl kinase using ClyA nanopore tweezers
Nature Communications, 2022 Quantitative characterization of kinase conformational dynamics remains challenging. Here, the authors show that protein nanopore tweezers allow analyzing the conformational energy landscape and ligand binding of the Abl kinase domain.
Fanjun Li +4 more
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Distance-Based Configurational Entropy of Proteins from Molecular Dynamics Simulations. [PDF]
PLoS ONE, 2015 Estimation of configurational entropy from molecular dynamics trajectories is a difficult task which is often performed using quasi-harmonic or histogram analysis.
Federico Fogolari +8 more
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Characterisation of HOIP RBR E3 ligase conformational dynamics using integrative modelling
Scientific Reports, 2022 Multidomain proteins composed of individual domains connected by flexible linkers pose a challenge for structural studies due to their intrinsic conformational dynamics.
Marius Kausas +3 more
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Intrinsic determinants of prion protein neurotoxicity in Drosophila: from sequence to (dys)function
Frontiers in Molecular Neuroscience, 2023 Prion diseases are fatal brain disorders characterized by deposition of insoluble isoforms of the prion protein (PrP). The normal and pathogenic structures of PrP are relatively well known after decades of studies.
Alessandro Cembran +1 more
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