Results 1 to 10 of about 3,454,137 (301)
Conformational Dynamics of Insulin [PDF]
Frontiers in Endocrinology, 2011 We have exploited a prandial insulin analogue (insulin lispro, the active component of Humalog®; Eli Lilly and Co.) to elucidate the underlying structure and dynamics of insulin as a monomer in solution.
Qing-xin eHua +2 more
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Integrin Conformational Dynamics and Mechanotransduction
Cells, 2022 The function of the integrin family of receptors as central mediators of cell-extracellular matrix (ECM) and cell–cell adhesion requires a remarkable convergence of interactions and influences.
Reza Kolasangiani +2 more
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Nuclear magnetic resonance free ligand conformations and atomic resolution dynamics [PDF]
Magnetic Resonance, 2021 Knowledge of free ligand conformational preferences (energy minima) and conformational dynamics (rotational energy barriers) of small molecules in solution can guide drug design hypotheses and help rank ideas to bias syntheses towards more active ...
A. Y. S. Balazs +4 more
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Biophysica, 2022 Single-molecule Förster resonance energy transfer (smFRET) enables the deconvolution of various conformational substates of biomolecules. Over the past two decades, it has been widely used to understand the conformational dynamics of enzymes.
Mai Huynh, Bhaswati Sengupta
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Scientific Reports, 2021 G protein-coupled receptors (GPCRs) are the largest class of transmembrane proteins, making them an important target for therapeutics. Activation of these receptors is modulated by orthosteric ligands, which stabilize one or several states within a ...
Dennis D. Fernandes +10 more
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Reconciling mediating and slaving roles of water in protein conformational dynamics. [PDF]
PLoS ONE, 2013 Proteins accomplish their physiological functions with remarkably organized dynamic transitions among a hierarchical network of conformational substates.
Li Zhao, Wenzhao Li, Pu Tian
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Molecules, 2022 Elucidation of physicochemical mechanisms of enzymatic processes is one of the main tasks of modern biology. High efficiency and selectivity of enzymatic catalysis are mostly ensured by conformational dynamics of enzymes and substrates.
Lyubov Yu. Kanazhevskaya +6 more
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PLoS Computational Biology, 2009 Conformational ensembles are increasingly recognized as a useful representation to describe fundamental relationships between protein structure, dynamics and function.
Gregory D Friedland +4 more
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Dynamic conformational change regulates the protein-DNA recognition: an investigation on binding of a Y-family polymerase to its target DNA. [PDF]
PLoS Computational Biology, 2014 Protein-DNA recognition is a central biological process that governs the life of cells. A protein will often undergo a conformational transition to form the functional complex with its target DNA.
Xiakun Chu +7 more
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Scientific Reports, 2020 The zinc transcriptional regulator (ZitR) functions as a metalloregulator that fine tunes transcriptional regulation through zinc-dependent DNA binding. However, the molecular mechanism of zinc-driven allosteric control of the DNA binding to ZitR remains
Xinheng He +7 more
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