Results 51 to 60 of about 3,678,372 (337)

Intrinsic determinants of prion protein neurotoxicity in Drosophila: from sequence to (dys)function

Frontiers in Molecular Neuroscience, 2023
Prion diseases are fatal brain disorders characterized by deposition of insoluble isoforms of the prion protein (PrP). The normal and pathogenic structures of PrP are relatively well known after decades of studies.
Alessandro Cembran, Pedro Fernandez-Funez   +1 more
doaj   +1 more source

ABCE1 Controls Ribosome Recycling by an Asymmetric Dynamic Conformational Equilibrium

Cell Reports, 2019
Summary: The twin-ATPase ABCE1 has a vital function in mRNA translation by recycling terminated or stalled ribosomes. As for other functionally distinct ATP-binding cassette (ABC) proteins, the mechanochemical coupling of ATP hydrolysis to conformational
Giorgos Gouridis, Bianca Hetzert, Kristin Kiosze-Becker, Marijn de Boer, Holger Heinemann, Elina Nürenberg-Goloub, Thorben Cordes, Robert Tampé   +7 more
doaj   +1 more source

The Onset of Molecule‐Spanning Dynamics in Heat Shock Protein Hsp90

Advanced Science, 2023
Protein dynamics have been investigated on a wide range of time scales. Nano‐ and picosecond dynamics have been assigned to local fluctuations, while slower dynamics have been attributed to larger conformational changes.
Benedikt Sohmen, Christian Beck, Veronika Frank, Tilo Seydel, Ingo Hoffmann, Bianca Hermann, Mark Nüesch, Marco Grimaldo, Frank Schreiber, Steffen Wolf, Felix Roosen‐Runge, Thorsten Hugel   +11 more
doaj   +1 more source

Using Open Data to Rapidly Benchmark Biomolecular Simulations: Phospholipid Conformational Dynamics

bioRxiv, 2020
Molecular dynamics (MD) simulations are widely used to monitor time-resolved motions of biomacromolecules, although it often remains unknown how closely the conformational dynamics correspond to those occurring in real life.
H. Antila, T. Ferreira, Samuli Ollila, Markus S. Miettinen   +3 more
semanticscholar   +1 more source

Active-Site-Directed Inhibitors of Prolyl Oligopeptidase Abolish Its Conformational Dynamics [PDF]

, 2016
Deciphering conformational dynamics is crucial for understanding the biological functions of proteins and for designing compounds targeting them. In particular, providing an accurate description of microsecond–millisecond motions opens the opportunity ...
Bernadó, Bernadó, Boehr, Brandt, Canning, Cunningham, Delaglio, Di Daniel, Fülöp, Gelis, Henzler-Wildman, Hornak, Jacques, Jaeger, Jorgensen, Kaszuba, Kichik, Konarev, Korzhnev, Li, Mertens, Mulder, Myöhänen, Nevola, Palmer, Religa, Savolainen, Savolainen, Shan, Svergun, Svergun, Tarragó, Tugarinov, Venäläinen, Yoshimoto   +34 more
core   +3 more sources

Conformational dynamics modulating electron transfer

The Journal of Chemical Physics, 2022
Diffusional dynamics of the donor–acceptor distance are responsible for the appearance of a new time scale of diffusion over the distance of electronic tunneling in electron-transfer reactions. The distance dynamics compete with the medium polarization dynamics in the dynamics-controlled electron-transfer kinetics.
openaire   +3 more sources

Protein conformational transitions coupling with ligand interactions: Simulations from molecules to medicine

Medicine in Novel Technology and Devices, 2019
The functions and activities of proteins are closely related to their structures and dynamics, and their interactions with ligands. Knowledge of the mechanistic events of proteins’ conformational transitions and interactions with ligands is crucially ...
Dechang Li, Baohua Ji
doaj   +1 more source

Characterisation of HOIP RBR E3 ligase conformational dynamics using integrative modelling

Scientific Reports, 2022
Multidomain proteins composed of individual domains connected by flexible linkers pose a challenge for structural studies due to their intrinsic conformational dynamics.
Marius Kausas, Diego Esposito, Katrin Rittinger, Franca Fraternali   +3 more
doaj   +1 more source

Conformational Dynamics of Supramolecular Protein Assemblies in the EMDB [PDF]

, 2010
The Electron Microscopy Data Bank (EMDB) is a rapidly growing repository for the dissemination of structural data from single-particle reconstructions of supramolecular protein assemblies including motors, chaperones, cytoskeletal assemblies, and viral ...
Bathe, Mark, Kim, Do-Nyun, Nguyen, Cong-Tri   +2 more
core   +2 more sources

Conformational dynamics of STIM1 activation [PDF]

Nature Structural & Molecular Biology, 2013
The binding of stromal interaction molecule 1 (STIM1) to ORAI calcium channels is critical for store-operated calcium entry (SOCE), a calcium influx pathway conserved among nearly all vertebrate cells. Although many major steps of this pathway are well understood, crucial details regarding the mechanism of STIM1 activation remain unclear.
Stefan, Feske, Murali, Prakriya
openaire   +2 more sources