Results 31 to 40 of about 1,191,463 (297)

Can a simple measure of vigorous physical activity predict future mortality? Results from the OXCHECK study. [PDF]

, 2004
BACKGROUND: As epidemiological studies have become more complex, demands for short, easily administered measures of risk factors have increased. This study investigates whether such a measure of physical activity is associated with the risk of death from
Hillsdon, Melvyn, Jones, Lesley, Murphy, Mike, Thorogood, Margaret   +3 more
core   +2 more sources

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Association between grip strength and diabetes prevalence in black, South Asian, and white European ethnic groups: a cross-sectional study of 418,656 UK Biobank participants [PDF]

, 2017
Aims: To quantify the extent to which ethnic differences in muscular strength might account for the substantially higher prevalence of diabetes in black and South-Asian compared with white European adults.
Celis-Morales, C.A., Gill, J.M.R., Mackay, D.F., Ntuk, U.E., Pell, J.P., Sattar, N.   +5 more
core   +1 more source

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Pulmonary Dysfunction Is Associated With Sleep Study Abnormalities in Children With Sickle Cell Disease: A Multicenter Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Pulmonary dysfunction and sleep abnormalities are common in children with sickle cell disease (SCD) and are associated with worse clinical outcomes. Whether spirometry abnormalities are associated with polysomnography (PSG) findings remains unclear.
Ammar Saadoon Alishlash, Anis Rabbani Nourani, A. K. M. Fazlur Rahman, Dima Ezmigna, Tarig Ali‐Dinar   +4 more
wiley   +1 more source

Athlete biological passport: longitudinal biomarkers and statistics in the fight against doping

Arhiv za Higijenu Rada i Toksikologiju
As novel substances, short time windows, and limits of detection increasingly challenge direct methods of doping detection in sports, indirect tools inevitably take a greater role in the fight against it. One such tool is the athlete biological passport (
Dragčević Dora, Pandžić Jakšić Vlatka, Jakšić Ozren   +2 more
doaj   +1 more source

Oral finasteride use and sexual adverse events: signal detection from disproportionality analyses of data from the United States Food and Drug Administration Adverse Event Reporting System

Journal of Dermatological Treatment
Background Oral finasteride 1 milligram (1 mg) daily—which is a 5-alpha reductase inhibitor (5-ARI) approved by the Food and Drug Administration (FDA) for androgenetic alopecia—is linked to sexual adverse events (AEs). However, it remains unclear whether
Aditya K. Gupta, Mesbah Talukder, Greg Williams, Mary A. Bamimore   +3 more
doaj   +1 more source

Hemocytes of zebra mussels (Dreissena polymorpha) are relevant cells for the monitoring of environmental genotoxicity by the comet assay.

Frontiers in Genetics, 2015
The measure of DNA integrity by the single cell gel electrophoresis (SCGE) or comet assay is especially recommended for its sensitivity and its capacity for detecting different types of damages.
Marc Bonnard, Sandrine Joachim
doaj   +1 more source

Conflict Resolution Ability in Late Bilinguals Improves With Increased Second-Language Proficiency: ANT Evidence [PDF]

, 2019
Experimental data supporting the claim that bilingual speakers have superior cognitive control abilities are often questioned with respect to certain methodological limitations.
Myachykov, Andriy, Novitskiy, Nikolay, Shtyrov, Yury   +2 more
core   +2 more sources

‘They Need to Hear You Say It’: Healthcare Professionals’ Perspectives on Barriers and Enablers to End‐of‐Life Discussions With Adolescents and Young Adults With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT End‐of‐life conversations with adolescents and young adults (AYAs) with cancer rarely occur without the guidance of healthcare professionals. As a part of the ‘Difficult Discussions’ study, focused on palliative care and advance care planning discussions with AYAs with cancer, we investigated the factors that healthcare professionals identify ...
Justine Lee, Holly Evans, Claire E. Wakefield, Antoinette Anazodo, Richard J. Cohn, Brittany C. McGill, Elizabeth A. Lobb, Lori Wiener, Madeleine L. Juhrmann, Ursula M. Sansom‐Daly   +9 more
wiley   +1 more source