Results 51 to 60 of about 334,679 (233)

A Genome-Wide association Study of Obstructive Heart Defects among Participants in the National Birth Defects Prevention Study [PDF]

, 2022
Obstructive heart defects (OHDs) share common structural lesions in arteries and cardiac valves, accounting for ~25% of all congenital heart defects. OHDs are highly heritable, resulting from interplay among maternal exposures, genetic susceptibilities ...
Bhattacharyya, Sudeepa, Browne, Marilyn L, Cleves, Mario, Hobbs, Charlotte A, Jenkins, Mary M, Lomangino, Kevin, Lou, Xiang-Yang, Mitchell, Laura E, Nembhard, Wendy N, Nestoridi, Eirini, Olshan, Andrew F, Rashkin, Sara R, Romitti, Paul A, Shaw, Gary M, Witte, John S   +14 more
core   +1 more source

Maternal Homocysteine and Congenital Heart Defects

Journal of the American College of Cardiology, 2006
To the Editor: An estimated 80% of congenital heart defects result from an interaction between susceptibilities in parental and fetal genomes and environmental exposures including maternal lifestyle factors ([1][1]). We and others have recently reported that women who have congenital heart defect-
Weizhi Zhao, Charlotte A. Hobbs, S. Jill James, Stepan Melnyk, Sadia Malik, Mario A. Cleves   +5 more
openaire   +3 more sources

“There's no acknowledgement of what this does to people”: A qualitative exploration of mental health among parents of children with critical congenital heart defects

Journal of Clinical Nursing, 2018
AIMS AND OBJECTIVES The purpose of this study was to explore the psychological impact of parenting a child with a critical congenital heart defect and the feasibility and acceptability of integrating psychological services into paediatric cardiology care.
Sarah E. Woolf-King, Emily A. Arnold, S. Weiss, D. Teitel   +3 more
semanticscholar   +1 more source

Genetics of Congenital Heart Defects: The NKX2-5 Gene, a Key Player

Genes, 2016
Congenital heart defects (CHDs) represent the biggest fraction of morbid congenital anomalies worldwide. Owing to their complex inheritance patterns and multifactorial etiologies, these defects are difficult to identify before complete manifestation ...
I. Chung, G. Rajakumar
semanticscholar   +1 more source

Maternal folic acid supplementation and dietary folate intake and congenital heart defects

PLoS ONE, 2017
Background It has been reported that folic acid supplementation before and/or during pregnancy could reduce the risk of congenital heart defects (CHDs). However, the results from limited epidemiologic studies have been inconclusive.
B. Mao, J. Qiu, N. Zhao, Y. Shao, W. Dai, Xiaochun He, H. Cui, Xiaojuan Lin, Ling Lv, Zhongfeng Tang, Sijuan Xu, Huang Huang, Min Zhou, Xiaoying Xu, W. Qiu, Qing Liu, Yawei Zhang   +16 more
semanticscholar   +1 more source

FETAL CARDIAC STRUCTURE DETECTION FROM ULTRASOUND SEQUENCES [PDF]

, 2020
Fetal heart abnormalities are the most common congenital anomalies and are also the leading cause of infant mortality related to birth defects. More than one-third of all malformations found after delivery are congenital heart defects.
JACOB, RESHMI MARIAM REJI, PORKUMARAN, K., PRABAKAR, S.   +2 more
core   +1 more source

Identification of cardiac malformations in mice lacking Ptdsr using a novel high-throughput magnetic resonance imaging technique [PDF]

, 2004
BACKGROUND: Congenital heart defects are the leading non-infectious cause of death in children. Genetic studies in the mouse have been crucial to uncover new genes and signaling pathways associated with heart development and congenital heart disease. The
Bamforth, Simon D, Bhattacharya, Shoumo, Broadbent, Carol, Böse, Jens, Clarke, Kieran, Gruber, Achim D, Lengeling, Andreas, Neubauer, Stefan, Schneider, Jürgen E   +8 more
core   +3 more sources

Palliative procedures for congenital heart defects

Archives of Cardiovascular Diseases, 2009
Although total repair of some congenital heart defects is possible in young children, palliative procedures still play an important role in relieving patients' symptoms, particularly in emergent settings, when total correction or surgical repair is not available.
Hua Jing, Shi-Min Yuan
openaire   +3 more sources

Lessons Learned From Newborn Screening for Critical Congenital Heart Defects

Pediatrics, 2016
Newborn screening for critical congenital heart defects (CCHD) was added to the US Recommended Uniform Screening Panel in 2011. Within 4 years, 46 states and the District of Columbia had adopted it into their newborn screening program, leading to CCHD ...
M. Oster, S. Aucott, Jill Glidewell, J. Hackell, L. Kochilas, G. Martin, Julia C. Phillippi, N. Pinto, Annamarie Saarinen, M. Sontag, A. Kemper   +10 more
semanticscholar   +1 more source

Ethnic and socioeconomic variation in incidence of congenital heart defects

Archives of Disease in Childhood, 2016
Introduction Ethnic differences in the birth prevalence of congenital heart defects (CHDs) have been reported; however, studies of the contemporary UK population are lacking.
R. Knowles, D. Ridout, S. Crowe, C. Bull, J. Wray, J. Tregay, R. Franklin, D. Barron, D. Cunningham, R. Parslow, K. Brown   +10 more
semanticscholar   +1 more source