Results 51 to 60 of about 3,896,028 (254)

A Spatiotemporal Single‐Cell Atlas Uncovers Dysregulated ECM Dynamics and Septal Remodeling Arrest in Human Ventricular Septal Defects

Advanced Science, EarlyView.
Integrating single‐cell and spatial transcriptomics reveals human ventricular septal defect (VSD) as a disease of microenvironmental insufficiency and structural remodeling arrest. Attenuated endothelial‐fibroblast crosstalk, alongside downregulated THBS1/TGF‐β1 and MMP2 signaling networks, impairs the endothelial‐to‐mesenchymal transition (EndoMT) and
Xiaoyuan Zhang, Lun Zhu, Ze Sun, Ruolin Jia, Ziming Wang, Jiayao Zhao, Bohao Liu, Haiqing Xiong, Xiaowei Yu, Yanzhu Yue   +9 more
wiley   +1 more source

Comparison of mitral regurgitation severity assessments based on magnetic resonance imaging and echocardiography in patients with hypertrophic cardiomyopathy

Scientific Reports, 2021
Mitral regurgitation (MR), which is one of the factors responsible for heart failure symptoms and the development of atrial fibrillation, is an important feature of hypertrophic cardiomyopathy (HCM), and its presence affects which treatment options are ...
Mateusz Śpiewak, Mariusz Kłopotowski, Ewa Kowalik, Łukasz Mazurkiewicz, Katarzyna Kożuch, Joanna Petryka-Mazurkiewicz, Barbara Miłosz-Wieczorek, Adam Witkowski, Anna Klisiewicz, Magdalena Marczak   +9 more
doaj   +1 more source

Age distribution of identified congenital heart diseases.

, 2015
Age distribution of identified congenital heart diseases.
Chun-Fang Shan (789879), Yi-Tong Ma (317802), Fen Liu (317808), Ying Huang (53474), Xiao-Ming Gao (419957), Xiang Xie (317801), Yi-Ning Yang (317803), Xiang Ma (317806), Xiao-Mei Li (110713), Bang-Dang Chen (317807), Zhen-Yan Fu (317804)   +10 more
core   +1 more source

An Adenoviral‐Vectored Tp0326 Vaccine Elicits Robust Functional Antibodies to Prevent Treponema pallidum Dissemination in a Rabbit Model

Advanced Science, EarlyView.
Vaccination promotes cellular infiltration into primary lesions and effectively inhibits T. pallidum dissemination to distal organs. Notably, transfer of lesion tissue from immunized animals fails to establish infection in naive recipients, confirming specific protective immunity.
Yinbo Jiang, Xinyuan Li, Lixia Huang, Xiangcai Zhang, Wujian Ke   +4 more
wiley   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

Alkylating Agent–Induced FANCL Impairment Damages Pulmonary Arterial, Venous, and Microvascular Endothelial Cells and Predisposes to PAH/PVOD

Advanced Science, EarlyView.
This study establishes a novel cisplatin‐induced rat model of PAH/PVOD and identifies a conserved mechanistic axis—FANCL impairment, DNA damage accumulation, and endothelial dysfunction—triggered by cisplatin or mitomycin C across pulmonary arteries, veins, and microvessels.
Shiyun Liu, Yufei Sun, Xinlei Wu, Haixia Chen, Shaocong Mo, Zichong Li, Yiwei Gong, Xiaoqian Shan, Yuanqi Li, Yaru Guan, Junqi Zhu, Han Yan, Min Du, Feng Wei, Peixin Ou, Ziyi Wang, Chenting Zhang, Lei Xu, Wenju Lu, Jian Wang, Kai Yang   +20 more
wiley   +1 more source

The impact of shock therapy on depression development and remote prognosis in cardiac resynchronization therapy recipients

Cardiology Journal
BACKGROUND: The aim of this study was to assess the incidence and clinical significance of depression in patients with cardiac resynchronization therapy with an implantable cardioverter-defibrillator (CRT-D).
Tomasz Podolecki, Robert Pudlo, Michał Mazurek, Monika Kozieł-Siołkowska, Joanna Boidol, Oskar Kowalski, Radosław Lenarczyk, Zbigniew Kalarus   +7 more
doaj   +1 more source

Epigenetics and Congenital Heart Diseases

, 2022
Congenital heart disease (CHD) is a frequent occurrence, with a prevalence rate of almost 1% in the general population. However, the pathophysiology of the anomalous heart development is still unclear in most patients screened.
Bonnet, Damien, Léa Linglart, Linglart, Léa, Damien Bonnet   +3 more
core   +1 more source

Implantable Systems for Cardiovascular Treatment and Monitoring: Comparative Insights From Intracardiovascular and Extracardiovascular Technologies

Advanced Intelligent Systems, EarlyView.
A unifying device–cardiovascular interface framework is presented to classify implantable cardiovascular technologies as intracardiovascular blood‐contacting systems or extracardiovascular tissue‐only and blood‐handling architectures. Cross‐class comparison across shared semiquantitative criteria, including blood‐contact burden, biomimicry ...
Bergo Nicolò, Semproni Federica, Maselli Martina, Colli Andrea, Cianchetti Matteo, Ciuti Gastone, Stefanini Cesare, Menciassi Arianna   +7 more
wiley   +1 more source

Congenital Heart Diseases in Neonates [PDF]

, 2010
Background: To determine the frequency of congenital heart diseases in neonates Methods: In this descriptive study, echocardiography was performed in all 459 suspected cases of congenital heart diseases.
Rehan Farooqui,Umme Farha Haroon ,Allauddin Niazi, Nosheen Rehan,Tayaba Khawar Butt ,Manal Niazi
core