Results 41 to 50 of about 3,538 (167)

Sector Classification of Unerupted Maxillary Canines: A Deep Learning‐Based Automated Framework Using Panoramic Radiographs

Orthodontics &Craniofacial Research, EarlyView.
ABSTRACT Objectives To develop a deep learning‐based framework to automate sector classification of unerupted maxillary canines (UMCs), assessing its accuracy and reliability compared to human ones. Material and Methods One thousand five hundred twenty‐eight UMCs from digital panoramic radiographs (PRs) were selected using data from the Dental ...
Marzio Galdi, Davide Cannatà, Flavia Celentano, Luigia Rizzo, Domenico Rossi, Tecla Bocchino, Genoveffa Tortora, Stefano Martina   +7 more
wiley   +1 more source

Paediatric hypopituitarism: a case report and management challenges in a resource poor setting

The Pan African Medical Journal, 2020
Hypopituitarism, a deficiency of one or more of the hormones produced by the pituitary gland, is a rare disorder. It can be congenital or acquired. Case report on childhood hypopituitarism is rare in Nigeria. We present a 15-year-old boy, second of a set
Isaac Oludare Oluwayemi, Oladele Simeon Olatunya, Ezra Olatunde Ogundare, Adebukola Bidemi Ajite, Adefunke Olarinre Babatola, Adewuyi Temidayo Adeniyi, Akinwumi Kolawole Komolafe   +6 more
doaj   +1 more source

Representation, medical examination, and the effectiveness of underwriting: Evidence from a life and health insurance company

Risk Management and Insurance Review, EarlyView.
Abstract This study examines whether underwriting methods—representation, medical examination, extra premiums, and coverage—effectively mitigate adverse selection using data from an insurance company. Regarding representation, we focus on statements disclosing pre‐existing medical conditions.
Chia‐Ling Ho, Gene Lai, Chen‐Hsu Liao, Zifen Zeng   +3 more
wiley   +1 more source

Clinical Challenges in Transition to Adult Care for Young People With Endocrinopathies

Clinical Endocrinology, Volume 105, Issue 1, Page 14-21, July 2026.
ABSTRACT The complexity of transition of pediatric patients to adult care is well recognized, with a multidisciplinary approach widely agreed to be essential. Despite extensive existing literature in this area, practical guidance as to the management of specific medical aspects and how to address these with patients and families is lacking, with little
Margaret Zacharin, Quynh‐Nhu Nguyen
wiley   +1 more source

Pituitary stalk interruption syndrome presenting in a euthyroid adult with short stature

Radiology Case Reports, 2018
Pituitary stalk interruption syndrome (PSIS) is a distinct and rare clinical entity responsible for congenital hypopituitarism resulting in deficiency of pituitary hormones with deficiency of the growth hormone (100%) and gonadotropins (97.2%) being its ...
Atif Nawaz, MBBS, FCPS-I, FRCR-I, Muhammad Azeemuddin, MBBS,MCPS,FCPS, Jehanzeb Shahid, MBBS,FCPS-I   +2 more
doaj   +1 more source

From Multiple Congenital Anomalies to Pituitary Gland Malformation: Wide Spectrum of Clinical Features in a Family With FOXA2 Variant

American Journal of Medical Genetics Part A, Volume 200, Issue 6, Page 1452-1457, June 2026.
ABSTRACT FOXA2 (hepatocyte nuclear factor‐3β, HNF‐3β) encodes a transcriptional activator involved in early embryogenesis, particularly in the patterning and differentiation of midline structures such as the neural tube, foregut, and pituitary gland. Its role in human pathogenesis was first suspected when patients with deletion of chromosome 20p11.2 ...
Christopher Connolly, Hemant A. Parmar, Lauren Hipp, Tomoyasu Higashimoto   +3 more
wiley   +1 more source

Next‐Generation Strategies for Neural Repair and Regeneration: Neural Organoid Transplantation in the CNS

Cell Proliferation, Volume 59, Issue 6, June 2026.
Neurological disorders are hard to treat. Stem cell‐derived neural organoids enable research, and their transplantation aids CNS therapy, with this article reviewing relevant advances, challenges and prospects. ABSTRACT Neurological disorders are often devastating and notoriously difficult to repair, creating an urgent need for novel research models ...
Yutong Wang, Jinrui Li, Xingjia Mao, Wanyu Wang, Yansong Li, Xuefei Hu, Jinjie Zhong, Fengdong Zhao, Linlin Wang   +8 more
wiley   +1 more source

Diagnosis and management of congenital hypopituitarism in children

Archives de Pédiatrie
Hypopituitarism (or pituitary deficiency) is a rare disease with an estimated prevalence of between 1/16,000 and 1/26,000 individuals, defined by insufficient production of one or several anterior pituitary hormones (growth hormone [GH], thyroid-stimulating hormone [TSH], adrenocorticotropic hormone [ACTH], luteinizing hormone [LH], follicle ...
Castets, Sarah, Vergier, Julia, Reynaud, Rachel, Thomas-Teinturier, Cécile, Villanueva, Carine, Amsellem, Jessica, Coutant, Régis, Barat, Pascal, Brun, Gilles, Quoc, Emmanuel Bui, Carel, Jean Claude, de Filippo, Gian Paolo, Kipnis, Clara, Martinerie, Laetitia, Léger, Juliane, Saveanu, Alexandru, Teissier, Natacha   +16 more
openaire   +3 more sources

Anterior pituitary hormone effects on hepatic functions in infants with congenital hypopituitarism

Annals of Hepatology, 2007
Background: Congenital hypopituitarism is an uncommon cause of neonatal cholestasis. Little is known about the effect of anterior pituitary hormone on hepatic functions.Methods: A retrospective review of the medical charts of eight infants with ...
Wikrom Karnsakul;, Pairunyar Sawathiparnich;, Saroj Nimkarn;, Supawadee Likitmaskul;, Jeerunda Santiprabhob;, Prapun Aanpreung   +5 more
doaj   +1 more source

Regulation of PHOX2B gene expression by the long non‐coding natural antisense RNA PHOX2B‐AS1

The FEBS Journal, Volume 293, Issue 12, Page 3502-3527, June 2026.
PHOX2B is a transcription factor essential for autonomic nervous system development. We identify and characterize PHOX2B‐AS1, a human long non‐coding antisense transcript at the PHOX2B locus, along with its murine counterpart. Our findings reveal bidirectional transcription and reciprocal regulation: PHOX2B activates PHOX2B‐AS1, whereas PHOX2B‐AS1 ...
Simona Di Lascio, Ana Lucia Cuadros Gamboa, Martina Bertocchi, Filippo Chiesa, Francesca Cargnin, Ettore Mosca, Paride Pelucchi, Viviana Tritto, Stefania Corti, Isabella Ceccherini, Paola Riva, Roberta Benfante, Diego Fornasari   +12 more
wiley   +1 more source