Results 21 to 30 of about 8,099 (218)
The “pain matrix” in pain-free individuals [PDF]
, 2016 Human functional imaging provides a correlative picture of brain activity during pain. A particular set of central nervous system structures (eg, the anterior cingulate cortex, thalamus, and insula) consistently respond to transient nociceptive stimuli ...
Iannetti, Gian Domenico +3 more
core +1 more source
A Case Report of Congenital Insensitivity to Pain with Anhidrosis
罕见病研究, 2023 Congenital insensitivity to pain with anhidrosis (CIPA) is associated with Charcot arthropathy and is a rare clinical syndrome, with limited treatment options.
JIAO Yuhao, TIAN Ye, CAI Siyi
doaj +1 more source
Episodic neurologic disorders: syndromes, genes, and mechanisms. [PDF]
, 2013 Many neurologic diseases cause discrete episodic impairment in contrast with progressive deterioration. The symptoms of these episodic disorders exhibit striking variety.
Fu, Ying-Hui +2 more
core +2 more sources
A novel disorder reveals clathrin heavy chain-22 is essential for human pain and touch development [PDF]
, 2015 Congenital inability to feel pain is very rare but the identification of causative genes has yielded significant insights into pain pathways and also novel targets for pain treatment.
Al-Gazali, Lihadh +12 more
core +2 more sources
A rare case of congenital insensitivity to pain with anhydrosiss
Indian Journal of Pain, 2015 Congenital insensitivity to pain syndrome with anhydrosis (CIPA) is a rare inherited disorder. It is characterized by loss of pain and temperature sensation, lack of sweating and mild mental retardation.
Govardhani Yanamadala +3 more
doaj +1 more source
Genetics update: monogenetics, polygene disorders and the quest for modifying genes [PDF]
, 2018 The genetic channelopathies are a broad collection of diseases. Many ion channel genes demonstrate wide phenotypic pleiotropy, but nonetheless concerted efforts have been made to characterise genotype-phenotype relationships.
Symonds, Joseph D., Zuberi, Sameer M.
core +1 more source
Indian Journal of Ophthalmology, 2021 Purpose: Congenital corneal anesthesia (CCA) is a rare clinical entity that poses a diagnostic dilemma, particularly in the pediatric age group with very little literature on this.
Madhumita Gopal +4 more
doaj +1 more source
Norrbottnian congenital insensitivity to pain
Acta Orthopaedica, 2006 Congenital insensitivity to pain is a rare hereditary neuropathy. We present patients from a large family in Norrbotten, Sweden with a mutation in the nerve growth factor beta gene (NGFbeta). Using a model of recessive inheritance, we identified an 8.3-Mb region on chromosome 1p11.2-p13.2 shared by the affected individuals in the family.
openaire +4 more sources
Total hip arthroplasty in a patient with congenital insensitivity to pain: a case report
Journal of Medical Case Reports, 2012 Introduction Congenital insensitivity to pain, a rare neurological entity, is characterized by varying degrees of sensory loss and autonomic dysfunction. Orthopedic manifestations of congenital insensitivity to pain include delayed diagnosis of fractures,
Erdil Mehmet +4 more
doaj +1 more source
Tomography, 2023 Hereditary sensory and autonomic neuropathy type 4 (HSAN4), also known as congenital insensitivity to pain with anhidrosis (CIPA), is a rare genetic disorder caused by NTRK1 gene mutations, affecting nerve growth factor signaling. This study investigates
Cheng-Chun Chiang +5 more
doaj +1 more source