Results 41 to 50 of about 8,099 (218)
JA Clinical Reports, 2018 Background Congenital insensitivity to pain with anhidrosis (CIPA) is a rare autosomal recessive disease characterized by unexplained fever, systemic insensitivity to pain, anhidrosis, and mental distress.
Yoko Takeuchi +5 more
doaj +1 more source
Nav1.7 and other voltage-gated sodium channels as drug targets for pain relief [PDF]
, 2016 INTRODUCTION: Chronic pain is a massive clinical problem. We discuss the potential of subtype selective sodium channel blockers that may provide analgesia with limited side effects.
Emery, EC, Luiz, AP, Wood, JN
core +1 more source
Congenital Insensibility to Pain
Medisur, 2023 Congenital insensitivity to pain is a condition that is present at birth, the affected individual is unable to perceive physical pain. The main symptoms include: wounds, bruises, fractures, self-mutilations, which can go unnoticed due to lack of ...
Carlos Gustavo López Barrionuevo +2 more
doaj
Joint Attention, Union with God, and the Dark Night of the Soul [PDF]
, 2013 Eleonore Stump has argued that the fulfilment of union between God and human beings requires a mode of relatedness that can be compared to joint attention, a phenomenon studied in contemporary experimental psychology.
Bungum, Donald
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A Case Report of Congenital Insensitivity to Pain and Anhidrosis (CIPA) [PDF]
, 2012 How to Cite this Article: Karimi M, Fallah R. A Case Report of Congenital Insensitivity to Pain and Anhidrosis (CIPA). Iran J Child Neurol 2012; 6(3): 45-48.
FALLAH, Razieh, KARIMI, Mehran
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Novel SCN9A mutations underlying extreme pain phenotypes: unexpected electrophysiological and clinical phenotype correlations. [PDF]
, 2015 The importance of NaV1.7 (encoded by SCN9A) in the regulation of pain sensing is exemplified by the heterogeneity of clinical phenotypes associated with its mutation.
Cox, James J +6 more
core +3 more sources
Congenital insensitivity to pain and anhidrosis
Indian Journal of Orthopaedics, 2011 Congenital insensitivity to pain and anhidrosis (CIPA) is a rare reported entity characterised by disturbance in the pain and temperature perception due to involvement of the autonomic and sensory nervous system. It is an autosomal recessive trait with several defects of the gene NTRK1 coding for the neurotrophic tyrosine kinase - a nerve growth factor
Sasnur, Ashok H +2 more
openaire +3 more sources
Evaluation of behavior in transgenic mouse models to understand human congenital pain conditions [PDF]
, 2018 BACKGROUND: Containing a brain for signal processing and decision making, and a peripheral component for sensation and response, the nervous system provides higher organisms a powerful method of interacting with their environment.
Bullock, Daniel
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Clinical Genetics, EarlyView.Comprehensive clinical description of 12 subjects with pathogenic PRKAR1B variants, including two heterozygous deletions supporting haploinsufficiency as a possible mechanism of disease, providing valuable insight into the pathophysiology of MASNS and setting a framework upon which to design future mechanistic studies of PKA signaling in brain ...
Sebastian Burkart +17 more
wiley +1 more source
Congenital insensitivity to pain and anhidrosis: A case report from South India
Indian Journal of Dermatology, 2012 Congenital insensitivity to pain with anhidrosis, also known as hereditary sensory and autonomic neuropathy type IV, is an autosomal recessive disorder characterized by the congenital lack of pain sensation, inability to sweat, episodes of recurrent ...
Carounanidy Udayashankar +2 more
doaj +1 more source