Results 51 to 60 of about 8,099 (218)

“It’s the end of the world as we know it and we feel fantastic: examining the end of suffering” [PDF]

, 2018
This paper examines the consequences of the transhumanist goal to eliminate the suffering of all sentient beings. While transhumanists identify numerous approaches to this goal, the endgame is genetic modification of humans and natural predators ...
Renstrom, Joelle
core  

Barriers to the Accessibility of Childcare Services for Children With Disabilities Aged 0 to 5 Years: Perspectives of Parents and Childcare Staff

Children &Society, EarlyView.
ABSTRACT According to Article 23 of the United Nations Convention on the Rights of the Child, children with disabilities are entitled to education, including access to high‐quality childcare services. Despite international and national commitments to inclusion, persistent obstacles continue to limit equitable access to childcare services for children ...
François Routhier, Josiane Lettre, Fidélia Longchamps, Gbetogo Maxime Kiki, Chantal Desmarais, Marie Grandisson, Ernesto Morales, Marie‐Eve Lamontagne, Francine Julien‐Gauthier, W. Ben Mortenson, Debra Field, Jill G. Zwicker, Wenonah Campbell, Michelle Phoenix, Marie‐Claude Belleau, Francine Tellier, Stéfanie Lamothe, Jason Gordon, Keely Edgington, Gabrielle Gagnon, Michelle Goulet, Anne‐Marie Guillot, Bobbi Taylor, Michelle Wan   +23 more
wiley   +1 more source

An Inversion Disrupting FAM134B Is Associated with Sensory Neuropathy in the Border Collie Dog Breed [PDF]

, 2016
Sensory neuropathy in the Border Collie is a severe neurological disorder caused by the degeneration of sensory and, to a lesser extent, motor nerve cells with clinical signs starting between 2 and 7 months of age.
Beltran, E, De Risio, L, Forman, O P, Gutierrez-Quintana, R, Hitti, R J, Jenkins, C A, Mellersh, C, O'Brien, D P, Pettitt, L, Shelton, G D   +9 more
core   +4 more sources

Spaceborne and spaceborn: Physiological aspects of pregnancy and birth during interplanetary flight

Experimental Physiology, EarlyView.
Abstract Crewed interplanetary return missions that are on the planning horizon will take years, more than enough time for initiation and completion of a pregnancy. Pregnancy is viewed as a sequence of processes – fertilization, blastocyst formation, implantation, gastrulation, placentation, organogenesis, gross morphogenesis, birth and neonatal ...
Arun V. Holden
wiley   +1 more source

The Israeli National Genetic database: a 10-year experience [PDF]

, 2017
BACKGROUND: The Israeli National and Ethnic Mutation database ( http://server.goldenhelix.org/israeli ) was launched in September 2006 on the ETHNOS software to include clinically relevant genomic variants reported among Jewish and Arab Israeli patients.
Patrinos, G.P. (George P.), Zlotogora, J. (Joël)   +1 more
core   +8 more sources

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, Volume 16, Issue 2, Page 252-267, February 2026.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Congenital insensitivity to pain: Case report of a rare entity

Indian Journal of Paediatric Dermatology, 2018
Hereditary sensory and autonomic neuropathies (HSANs) are a group of disorders characterized by insensitivity to noxious stimuli and autonomic dysfunction, associated with pathological abnormalities of the peripheral nerves.
Swati Dahiya, Kondajji Ramchandra Vijayalakshmi, Mubeen Khan   +2 more
doaj   +1 more source

Hypnotic analgesia reduces brain responses to pain seen in others. [PDF]

, 2017
Brain responses to pain experienced by oneself or seen in other people show consistent overlap in the pain processing network, particularly anterior insula, supporting the view that pain empathy partly relies on neural processes engaged by self ...
A Krishnan, A Öhman, AR Aron, BC Bernhardt, BE Depue, C Corradi-Dell’Acqua, C Lamm, C Lamm, D Kleinböhl, F Vignemont De, GD Iannetti, J Decety, JT Buhle, JW Peirce, K Friston, LE Simons, M Faymonville, M Faymonville, MC Anderson, MV Saarela, N Danziger, OM Klimecki, P Rainville, RE Shor, RH Gracely, T Singer, T Singer, TD Wager, V Legrain, WK Simmons, Y Cojan, Y Cojan   +31 more
core   +4 more sources

The parabss1 Drosophila melanogaster as Model for Chronic Nociception: Insights Into Cannabidiol Analgesic Effects

European Journal of Pain, Volume 30, Issue 2, February 2026.
ABSTRACT Background Chronic pain, which is often unrelated to ongoing injury, is poorly understood and difficult to treat. Genetic studies have identified voltage‐gated sodium (Nav) channels, particularly gain‐of‐function mutations such as L858F and R1150W in human NaV1.7, as involved in the development of chronic pain. Methods A chronic pain model was
Serena Mares Malta, Lucas Ian Veloso Correia, Alexandre Souza Marquez, Lucas Matos Martins Bernardes, John George Howland, Ana Paula Mendes‐Silva, Foued Salmen Espíndola, Carlos Ueira‐Vieira   +7 more
wiley   +1 more source

Congenital Insensitivity to Pain: A Fatal Entity

Indian Journal of Medical Specialities
Congenital insensitivity to pain (CIP), also known as congenital analgesia, is an autosomal recessive, extraordinarily rare condition, in which a patient cannot feel pain in any part of his or her body.
Debojit Biswas, Paramita Thander, Moumita Pati, Pankaj Halder   +3 more
doaj   +1 more source