Results 1 to 10 of about 4,402 (119)

Congenital lung malformations [PDF]

Nature Reviews Disease Primers, 2023
Congenital lung malformations (CLMs) are rare developmental anomalies of the lung, including congenital pulmonary airway malformations (CPAM), bronchopulmonary sequestration, congenital lobar overinflation, bronchogenic cyst and isolated congenital bronchial atresia. CLMs occur in 4 out of 10,000 live births.
Federica Pederiva, Steven S. Rothenberg, Nigel Hall, Hanneke Ijsselstijn, Kenneth K. Y. Wong, Jan von der Thüsen, Pierluigi Ciet, Reuven Achiron, Adamo Pio d’Adamo, J. Marco Schnater   +9 more
openaire   +6 more sources

Nuclear factor I-C disrupts cellular homeostasis between autophagy and apoptosis via miR-200b-Ambra1 in neural tube defects

Cell Death and Disease, 2021
Impaired autophagy and excessive apoptosis disrupt cellular homeostasis and contribute to neural tube defects (NTDs), which are a group of fatal and disabling birth defects caused by the failure of neural tube closure during early embryonic development ...
Wanqi Huang, Tianchu Huang, Yusi Liu, Jialin Fu, Xiaowei Wei, Dan Liu, Wei Ma, Hui Gu, Zhengwei Yuan   +8 more
doaj   +1 more source

PIWI-interacting RNA sequencing profiles in maternal plasma-derived exosomes reveal novel non-invasive prenatal biomarkers for the early diagnosis of nonsyndromic cleft lip and palate

EBioMedicine, 2021
Background: Congenital malformations are common birth defects with high neonatal morbidity and mortality. It is essential to find simpler and more efficient biomarkers for early prenatal diagnosis. Therefore, we investigated PIWI-interacting RNAs (piRNAs)
Shanshan Jia, Qiang Zhang, Yu Wang, Yanfu Wang, Dan Liu, Yiwen He, Xiaowei Wei, Hui Gu, Wei Ma, Wenting Luo, Zhengwei Yuan   +10 more
doaj   +1 more source

Impact of prenatal exposure to metallic elements on neural tube defects: Insights from human investigations

Ecotoxicology and Environmental Safety, 2023
Metallic elements play a pivotal role in maternal and fetal health. Metals can cross the placental barrier and be absorbed by fetuses, where they may affect closure of the neural tube during embryonic development. Neural tube defects (NTDs), which result
Wanqi Huang, Jialin Fu, Zhengwei Yuan, Hui Gu   +3 more
doaj   +1 more source

Intra-amniotic transplantation of brain-derived neurotrophic factor-modified mesenchymal stem cells treatment for rat fetuses with spina bifida aperta

Stem Cell Research & Therapy, 2022
Background Spina bifida aperta (SBA) is a relatively common clinical type of neural tube defect. Although prenatal fetal surgery has been proven to be an effective treatment for SBA, the recovery of neurological function remains unsatisfactory due to ...
Wei Ma, Xiaowei Wei, Hui Gu, Dan Liu, Wenting Luo, Songying Cao, Shanshan Jia, Yiwen He, Lizhu Chen, Yuzuo Bai, Zhengwei Yuan   +10 more
doaj   +1 more source

Small but strong: the emerging role of small nucleolar RNA in cardiovascular diseases

Frontiers in Cell and Developmental Biology, 2023
Cardiovascular diseases (CVDs) are the leading cause of mortality and disability worldwide. Numerous studies have demonstrated that non-coding RNAs (ncRNAs) play a primary role in CVD development.
Xue Sun, Xue Sun, Gebang Wang, Wenting Luo, Hui Gu, Wei Ma, Xiaowei Wei, Dan Liu, Shanshan Jia, Songying Cao, Yu Wang, Zhengwei Yuan   +11 more
doaj   +1 more source

Congenital malformations [PDF]

The Journal of Maternal-Fetal & Neonatal Medicine, 2012
Congenital malformations are single or multiple defects of the morphogenesis of organs or body districts identifiable at birth or during the intrauterine life. Their global birth prevalence is about 2-3%. Both genetic and environmental factors, as well as their combination in a multifactorial contest, may induce congenital defects.
Corsello, G, Giuffre, M
openaire   +3 more sources

Tumor Necrosis Factor Alpha Signaling and Organogenesis

Frontiers in Cell and Developmental Biology, 2021
Tumor necrosis factor alpha (TNF-α) plays important roles in processes such as immunomodulation, fever, inflammatory response, inhibition of tumor formation, and inhibition of viral replication.
Kai You, Hui Gu, Zhengwei Yuan, Xuewen Xu, Xuewen Xu   +4 more
doaj   +1 more source

Intra-Amniotic Delivery of CRMP4 siRNA Improves Mesenchymal Stem Cell Therapy in a Rat Spina Bifida Model

Molecular Therapy: Nucleic Acids, 2020
Neural tube defects (NTDs) result in prenatal mortality and lifelong morbidity, and available treatments have limited efficacy. We previously suggested that prenatal bone marrow-derived mesenchymal stem cell (BMSC) transplantation could treat neuron ...
Xiaowei Wei, Songying Cao, Wei Ma, Chaonan Zhang, Hui Gu, Dan Liu, Wenting Luo, Yuzuo Bai, Weilin Wang, Zhengwei Yuan   +9 more
doaj   +1 more source

Fluoride increases the susceptibility of developmental dysplasia of the hip via increasing capsular laxity triggered by cell apoptosis and oxidative stress in vivo and in vitro

Ecotoxicology and Environmental Safety, 2022
The etiology of developmental dysplasia of the hip (DDH) is multifactorial, including breech presentation and hip capsular laxity. In particular, hip laxity is the main contributor to DDH by changing the ratio and distribution of collagens.
Weizheng Zhou, Wenting Luo, Dan Liu, Federico Canavese, Lianyong Li, Qun Zhao   +5 more
doaj   +1 more source