Results 41 to 50 of about 11,985 (168)

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Hammersmith Infant Neurological Examination at 3 Months in Infants at Risk for Congenital Infections: A Cohort Study

Journal of Paediatrics and Child Health, Volume 62, Issue 3, Page 374-380, March 2026.
ABSTRACT Introduction STORCH refers to a group of congenital infections (syphilis, toxoplasmosis, rubella, cytomegalovirus and herpes) that can impact the central nervous system. As clinical signs may not appear until several months or years after birth, the early detection of risk in STORCH‐exposed infants has been challenging, and the use of ...
Karen Cristine Oliveira de Azambuja, Amanda de Arguelho Oliveira Arguelho, Meyene Duque Weber, Lorrainy Marques da Silva Dutra, Tathiana Ghisi de Souza, Daniele Soares‐Marangoni   +5 more
wiley   +1 more source

The Zika outbreak of the 21st century. [PDF]

, 2016
The Zika virus outbreak has captivated the attention of the global audience and information has spread rapidly and wildly through the internet and other media channels.
Ansari, Aftab, Chang, Christopher, Gershwin, M Eric, Ortiz, Kristina   +3 more
core   +1 more source

Unveiling the Molecular Profile and Antiviral Potential of Costus arabicus L. Against Zika Virus

Chemistry &Biodiversity, Volume 23, Issue 2, February 2026.
Analysis of the chemical profile and antiviral potential of Costus arabicus L. extracts. ABSTRACT Widely used in Brazilian folk medicine, Costus arabicus L. (Canarana) is a herbaceous plant with promising pharmacological potential. Here, we profile the molecular composition of extracts from different plant organs and evaluate their in vitro activity ...
Alice Rhelly V. Carvalho, José Diogo E. Reis, Ariane Coelho Ferraz, Marília Bueno da Silva Menegatto, Juliana da C. Lopes, Sônia das G. S. R. Pamplona, Milton N. da Silva, Cintia Lopes de Brito Magalhães, Paulo Wender P. Gomes, Consuelo Yumiko Yoshioka e Silva   +9 more
wiley   +1 more source

Reflections on Health Promotion and Disability in Low and Middle-Income Countries: Case Study of Parent-Support Programmes for Children with Congenital Zika Syndrome. [PDF]

, 2018
Universal health coverage (UHC) has been adopted by many countries as a national target for 2030. People with disabilities need to be included within efforts towards UHC, as they are a large group making up 15% of the world's population and are more ...
Duttine, Antony, Kuper, Hannah, Smythe, Tracey   +2 more
core   +2 more sources

Clinical Presentation and Treatment of Hyperemesis Gravidarum in a Lady Carrying Twins in the First Trimester: A Case Reports

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT We report a 12‐week‐old pauci‐geste carrying twins who experienced potentially fatal hyperemesis gravidarum. Clinical and paraclinical investigations revealed severe hypovolemic shock/dehydration, ionic disruption, undernutrition, and acute renal failure (GFR: 36.8 mL/min/1.73 m2 according to modified MDRD). The patient spent almost 3 weeks in
Kesheni Banyanga David, Carmel Mbalo Walemba, Vanessa Ndamuso Nshombo, Marc Burume, Bushambale Rudeha Agath, Laurent Kasongo, Germain Mugisho Matabaro, Gaston Masimango, Trésor Okamba Alangi, Philémon Matabishi, Patient Wimba Mijiriro   +10 more
wiley   +1 more source

Outbreak of Zika virus pathogenesis and quest of its vaccine development: Where do we stand now? [PDF]

, 2018
Zika virus (ZIKV) infection is a life-threatening tropical infection, mainly caused by mosquito bite. After a very long period of quietness, ZIKV infections have become a problematic issue again.
Aarti, Chirom, Aarti, Chirom, BARBABOSA PLIEGO, ALBERTO, BARBABOSA PLIEGO, ALBERTO, KHUSRO, AMEER, KHUSRO, AMEER, SANCHEZ APARICIO, PEDRO, SANCHEZ APARICIO, PEDRO   +7 more
core   +1 more source

Peli1 signaling blockade attenuates congenital zika syndrome

PLOS Pathogens, 2020
Zika virus (ZIKV) infects pregnant women and causes devastating congenital zika syndrome (CZS). How the virus is vertically transmitted to the fetus and induces neuronal loss remains unclear. We previously reported that Pellino (Peli)1, an E3 ubiquitin ligase, promotes p38MAPK activation in microglia and induction of lethal encephalitis by facilitating
Huanle Luo, Guangyu Li, Binbin Wang, Bing Tian, Junling Gao, Jing Zou, Shuizhen Shi, Shuang Zhu, Bi-Hung Peng, Awadalkareem Adam, Ariza Martinez, Kimberly Hein, Evandro R. Winkelmann, Yoseph Mahmoud, Xiaofei Zhou, Chao Shan, Shannan Rossi, Scott Weaver, Alan D. T. Barrett, Shao-Cong Sun, Wenbo Zhang, Pei-Yong Shi, Ping Wu, Tian Wang   +23 more
openaire   +4 more sources

Mosquito‐Borne Viruses of Clinical Significance

Health Science Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background Mosquito‐borne viruses represent a significant public health concern globally, with rising incidence rates leading to increased morbidity and mortality. This review aims to synthesize current knowledge regarding mosquito‐borne viruses, focusing on their geographic distribution, clinical impact, diagnostic challenges, treatment ...
Donath Damian
wiley   +1 more source

Toward Dual‐Function Nanoparticle Platforms for Arboviral Diagnostics and Vaccines: Advances, Challenges, and Future Prospects

Nano Select, Volume 7, Issue 2, February 2026.
This review explores nanoparticle (NP)‐based biosensors and nanovaccine platforms for arboviral infections, highlighting their design, performance, and translational potential. By comparing case studies across viruses, it identifies gold‐standard nanomaterials such as gold NPs (AuNPs), zinc oxide NPs (ZnONPs), molybdenum disulfide (MoS2) nanocomposites,
Peyman Halvaeikhanekahdani, Sajad Zandi, Qadeer Ahmad, Hadiseh Payravand   +3 more
wiley   +1 more source