Results 31 to 40 of about 579 (230)
“Critical” Terminology – Apropos of a Conjecture
Procedia Engineering, 2017 Abstract In 1959 J. E. Kelley and. M. Walker had published their well-known and famous method to optimize project schedules with relative precedence restraints and with time-cost tradeoff characteristics at the individual activities (CPM cost ). They had also elaborated basic terminology for interpreting results of calculations such as: Critical ...
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Ore's conjecture on color-critical graphs is almost true
Journal of Combinatorial Theory, Series B, 2014 A graph $G$ is $k$-critical if it has chromatic number $k$, but every proper subgraph of $G$ is $(k-1)$--colorable. Let $f_k(n)$ denote the minimum number of edges in an $n$-vertex $k$-critical graph. We give a lower bound, $f_k(n) \geq F(k,n)$, that is sharp for every $n=1 ({\rm mod} k-1)$. It is also sharp for $k=4$ and every $n\geq 6$.
Kostochka, Alexandr, Yancey, Matthew
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Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
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Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
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An overdetermined eigenvalue problem and the Critical Catenoid conjecture
, 2023 We consider the eigenvalue problem $Δ^{\mathbb{S}^2} ξ+ 2 ξ=0 $ in $ Ω$ and $ξ= 0 $ along $ \partial Ω$, being $Ω$ the complement of a disjoint and finite union of smooth and bounded simply connected regions in the two-sphere $\mathbb{S}^2$. Imposing that $|\nabla ξ|$ is locally constant along $\partial Ω$ and that $ξ$ has infinitely many maximum ...
Espinar, José M., Marín, Diego A.
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Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
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The critical Lazer–McKenna conjecture in low dimensions
Journal of Differential Equations, 2008 The author studies a problem related to the Laze-McKenna conjecture in the critical case and proves that the situation is drastically different in lower dimensions.
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PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
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