Results 41 to 50 of about 16,919 (269)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
What's wrong with science? [PDF]
, 2009 Here is an idea that might help save the world. It is that science, properly understood, provides us with the methodological key to the salvation of humanity.
Maxwell, N
core
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
“Critical” Terminology – Apropos of a Conjecture
Procedia Engineering, 2017 Abstract In 1959 J. E. Kelley and. M. Walker had published their well-known and famous method to optimize project schedules with relative precedence restraints and with time-cost tradeoff characteristics at the individual activities (CPM cost ). They had also elaborated basic terminology for interpreting results of calculations such as: Critical ...
openaire +1 more source
Ore's conjecture on color-critical graphs is almost true
Journal of Combinatorial Theory, Series B, 2014 A graph $G$ is $k$-critical if it has chromatic number $k$, but every proper subgraph of $G$ is $(k-1)$--colorable. Let $f_k(n)$ denote the minimum number of edges in an $n$-vertex $k$-critical graph. We give a lower bound, $f_k(n) \geq F(k,n)$, that is sharp for every $n=1 ({\rm mod} k-1)$. It is also sharp for $k=4$ and every $n\geq 6$.
Kostochka, Alexandr, Yancey, Matthew
openaire +2 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Filosofia da ciência como ferramenta microeconômica
Nova Economia, 2006 Neoclassical theory assumes perfect knowledge. In turn, Hayekian criticism of this theory affirms that this knowledge is the result of the competitive process, and therefore cannot be considered as a given. The "Hayek Problem" investigates the conditions
Fabio Barbieri
doaj
Some Critical Comments on Long 2013: "Why Libertarians Believe There is Only One Right" [PDF]
, 2014 This essay explains various significant errors, imprecisions, and omissions concerning libertarianism in Long 2013. The “right not to be aggressed against” is not, as such, the libertarian right because the ‘right to liberty’ must be that right (although
Lester, J. C.
core
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source