Results 31 to 40 of about 580 (224)
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
“Critical” Terminology – Apropos of a Conjecture
Procedia Engineering, 2017 Abstract In 1959 J. E. Kelley and. M. Walker had published their well-known and famous method to optimize project schedules with relative precedence restraints and with time-cost tradeoff characteristics at the individual activities (CPM cost ). They had also elaborated basic terminology for interpreting results of calculations such as: Critical ...
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Ore's conjecture on color-critical graphs is almost true
Journal of Combinatorial Theory, Series B, 2014 A graph $G$ is $k$-critical if it has chromatic number $k$, but every proper subgraph of $G$ is $(k-1)$--colorable. Let $f_k(n)$ denote the minimum number of edges in an $n$-vertex $k$-critical graph. We give a lower bound, $f_k(n) \geq F(k,n)$, that is sharp for every $n=1 ({\rm mod} k-1)$. It is also sharp for $k=4$ and every $n\geq 6$.
Alexandr V. Kostochka, Matthew P. Yancey
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On a conjecture for the critical behaviour of KAM tori [PDF]
, 2002 8 ...
BONETTO F, GENTILE, Guido
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The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Filosofia da ciência como ferramenta microeconômica
Nova Economia, 2006 Neoclassical theory assumes perfect knowledge. In turn, Hayekian criticism of this theory affirms that this knowledge is the result of the competitive process, and therefore cannot be considered as a given. The "Hayek Problem" investigates the conditions
Fabio Barbieri
doaj
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source