Results 21 to 30 of about 580 (224)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
A note on the double-critical graph conjecture
Discrete Mathematics, 2016 A connected $n$-chromatic graph $G$ is double-critical if for all the edges $xy$ of $G$, the graph $G-x-y$ is $(n-2)$-chromatic. In 1966, Erd\H os and Lovász conjectured that the only double-critical $n$-chromatic graph is $K_n$. This conjecture remains unresolved for $n \ge 6.$ In this short note, we verify this conjecture for claw-free graphs $G$ of ...
Huang, Hao, Yu, Alexander
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FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
On the Lazer-McKenna Conjecture Involving Critical and Super-critical Exponents [PDF]
Methods and Applications of Analysis, 2008 We prove the Lazer-McKenna conjecture for an elliptic problem of Ambrosetti-Prodi type with critical and supercritical nonlinearities by constructing solutions concentrating on higher dimensional manifolds, under some partially symmetric assumption on the domain.
Dancer, E. N., Yan, Shusen
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FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
HIST-Critical Graphs and Malkevitch's Conjecture
CoRRIn a given graph, a HIST is a spanning tree without $2$-valent vertices. Motivated by developing a better understanding of HIST-free graphs, i.e. graphs containing no HIST, in this article's first part we study HIST-critical graphs, i.e. HIST-free graphs in which every vertex-deleted subgraph does contain a HIST (e.g. a triangle).
Jan Goedgebeur +3 more
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On the strong perfect graph conjecture and critical graphs
Discrete Mathematics, 1982 In this paper we obtain some properties of graphs which are critical with respect to perfectness. Some alternate forms of Berge's [2] strong perfect graph conjecture are also given.
M. R. Sridharan, O. T. George
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
On Some Conjectures Concerning Critical Independent Sets of a Graph [PDF]
The Electronic Journal of Combinatorics, 2016 Let $G$ be a simple graph with vertex set $V(G)$. A set $S\subseteq V(G)$ is independent if no two vertices from $S$ are adjacent. For $X\subseteq V(G)$, the difference of $X$ is $d(X) = |X|-|N(X)|$ and an independent set $A$ is critical if $d(A) = \max \{d(X): X\subseteq V(G) \text{ is an independent set}\}$ (possibly $A=\emptyset$).
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source