Results 41 to 50 of about 579 (230)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Pressure Inside Hadrons: Criticism, Conjectures, and All That
Acta Physica Polonica BThe interpretation of the energy-momentum tensor form factor \(D(t)\) of hadrons in terms of pressure and shear force distributions is discussed, concerns raised in the literature are reviewed, and ways to reconcile the concerns with the interpretation are indicated.
C. Lorcé, P. Schweitzer
openaire +2 more sources
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
On Some Conjectures Concerning Critical Independent Sets of a Graph [PDF]
The Electronic Journal of Combinatorics, 2016 Let $G$ be a simple graph with vertex set $V(G)$. A set $S\subseteq V(G)$ is independent if no two vertices from $S$ are adjacent. For $X\subseteq V(G)$, the difference of $X$ is $d(X) = |X|-|N(X)|$ and an independent set $A$ is critical if $d(A) = \max \{d(X): X\subseteq V(G) \text{ is an independent set}\}$ (possibly $A=\emptyset$).
openaire +3 more sources
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
Strengthening the Murty–Simon conjecture on diameter 2 critical graphs
Discrete Mathematics, 2019 A graph is diameter-2-critical if its diameter is 2 but the removal of any edge increases the diameter. A well-studied conjecture, known as the Murty-Simon conjecture, states that any diameter-2-critical graph of order n has at most n${}^2$/4 edges, with equality if and only if G is a balanced complete bipartite graph.
Dailly, Antoine +2 more
openaire +5 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
HIST-Critical Graphs and Malkevitch's Conjecture
In a given graph, a HIST is a spanning tree without $2$-valent vertices. Motivated by developing a better understanding of HIST-free graphs, i.e. graphs containing no HIST, in this article's first part we study HIST-critical graphs, i.e. HIST-free graphs in which every vertex-deleted subgraph does contain a HIST (e.g. a triangle).
Goedgebeur, Jan +3 more
openaire +2 more sources