Results 1 to 10 of about 913,888 (143)

New modification of the hestenes-stiefel with strong wolfe line search [PDF]

, 2021
. The method of the nonlinear conjugate gradient is widely used in solving large-scale unconstrained optimization since been proven in solving optimization problems without using large memory storage.
Basri, Srimazzura, Japri, Nur Athira, Mamat, Mustafa   +2 more
core   +1 more source

Pharmacokinetics of Pullulan–Dexamethasone Conjugates in Retinal Drug Delivery

Pharmaceutics, 2021
The treatment of retinal diseases by intravitreal injections requires frequent administration unless drug delivery systems with long retention and controlled release are used.
Eva Kicková, Amir Sadeghi, Jooseppi Puranen, Shirin Tavakoli, Merve Sen, Veli-Pekka Ranta, Blanca Arango-Gonzalez, Sylvia Bolz, Marius Ueffing, Stefano Salmaso, Paolo Caliceti, Elisa Toropainen, Marika Ruponen, Arto Urtti   +13 more
doaj   +1 more source

Twenty Years of Research on Cyclodextrin Conjugates with PAMAM Dendrimers

Pharmaceutics, 2021
Recently, the number of gene and oligonucleotide drugs are increasing. Of various drug delivery systems (DDSs) for gene and oligonucleotide drugs, few examples of the clinical application of polymer as drug carriers are known, despite development of the ...
Hidetoshi Arima
doaj   +1 more source

Rhein–Amino Acid Ester Conjugates as Potential Antifungal Agents: Synthesis and Biological Evaluation

Molecules, 2023
In the search for crop protectants, amino acid ester conjugates have been widely investigated as potential antifungal agents. In this study, a series of rhein–amino acid ester conjugates were designed and synthesized in good yields, and their structures ...
Shunshun Chen, Meimei Wang, Linhua Yu, Jinchao Shi, Yong Zhang, Yao Tian, Li Li, Xiang Zhu, Junkai Li   +8 more
doaj   +1 more source

Novel G‐CSF conjugated anionic globular dendrimer: Preparation and biological activity assessment

Pharmacology Research & Perspectives, 2021
The most crucial role of granulocyte colony‐stimulating factor (G‐CSF) in the body is to increase the strength of immune system. In recent years, research on the use of nanoparticles in pharmaceuticals has been considered, most of which have been for ...
Seyed Shahaboddin Mousavi Motlagh, Mohammad Seyedhamzeh, Reza Ahangari Cohan, Mehdi Shafiee Ardestani, Behrouz Vaziri, Kayhan Azadmanesh, Sahar Saberi, Vahideh Masoumi   +7 more
doaj   +1 more source

Development of Phosphoramidite Reagents for the Synthesis of Base-Labile Oligonucleotides Modified with a Linear Aminoalkyl and Amino-PEG Linker at the 3′-End

Molecules, 2022
Oligonucleotides with an amino linker at the 3′-end are useful for the preparation of conjugated oligonucleotides. However, chemically modified nucleosides, which are unstable under basic conditions, cannot be incorporated into oligonucleotides using the
Takashi Osawa, Qin Ren, Satoshi Obika
doaj   +1 more source

Polysaccharide dextran-based conjugate for selective co-delivery of two synergistic drugs docetaxel and docosahexaenoic acid to tumor cells

Drug Delivery, 2023
Most chemotherapeutic agents are nonspecific distribution and cause systemic toxicities. Polysaccharide-based conjugates are promising strategies to overcome these drawbacks.
Peng Dong, Hongshuai Lv, Weiping Jia, Jiaojiao Liu, Si Wang, Xiaohai Li, Jinghua Hu, Ling Zhao, Yikang Shi   +8 more
doaj   +1 more source

The Bioinformatic and In Vitro Studies of Clostridioides Difficile Aminopeptidase M24 Revealed the Immunoreactive KKGIK Peptide

Cells, 2020
Clostridioides difficile (CD) is a Gram-positive pathogen responsible for CD-associated disease (CDAD), which is characterized by symptoms ranging from mild diarrhea to pseudomembranous colitis.
Katarzyna Pacyga, Agnieszka Razim, Gayane Martirosian, Małgorzata Aptekorz, Andrzej Szuba, Andrzej Gamian, Andrzej Myc, Sabina Górska   +7 more
doaj   +1 more source

Inhibition Mechanism of Chitooligosaccharide-Polyphenol Conjugates toward Polyphenoloxidase from Shrimp Cephalothorax

Molecules, 2023
Crustaceans are perishable with a short shelf-life. They are prone to deterioration after capture, particularly during handling, processing, and storage due to melanosis caused by polyphenoloxidase (PPO).
Ajay Mittal, Avtar Singh, Bin Zhang, Qiancheng Zhao, Soottawat Benjakul   +4 more
doaj   +1 more source

CONJUGATE NATURAL CONVECTION IN A POROUS ENCLOSURE SANDWICHED BY FINITE WALLS AND SUBJECTED TO CONVECTION COOLING CONDITION

Journal of Engineering and Sustainable Development, 2021
Steady conjugate natural convection heat transfer in a two-dimensional enclosure filled with fluid saturated porous medium is studied numerically. The two vertical boundaries of the enclosure are kept isothermally at same temperature, the horizontal ...
Hassan H. Hatem, Luma F. Ali
doaj   +1 more source