Results 1 to 10 of about 1,526,980 (375)
Antibody drug conjugate: the “biological missile” for targeted cancer therapy
Signal Transduction and Targeted Therapy, 2022 Antibody–drug conjugate (ADC) is typically composed of a monoclonal antibody (mAbs) covalently attached to a cytotoxic drug via a chemical linker. It combines both the advantages of highly specific targeting ability and highly potent killing effect to ...
Sifei Han, Chen Shi, Yu Zhang
exaly +2 more sources
New modification of the hestenes-stiefel with strong wolfe line search [PDF]
, 2021 . The method of the nonlinear conjugate gradient is widely used in solving large-scale unconstrained optimization since been proven in solving optimization problems without using large memory storage.
Basri, Srimazzura +2 more
core +1 more source
Pharmacokinetics of Pullulan–Dexamethasone Conjugates in Retinal Drug Delivery
Pharmaceutics, 2021 The treatment of retinal diseases by intravitreal injections requires frequent administration unless drug delivery systems with long retention and controlled release are used.
Eva Kicková +13 more
doaj +1 more source
On-demand biomanufacturing of protective conjugate vaccines
Science Advances, 2021 In vitro conjugate vaccine expression technology enables rapid and portable biosynthesis of protective antibacterial vaccines. Conjugate vaccines are among the most effective methods for preventing bacterial infections.
Jessica C. Stark +12 more
semanticscholar +1 more source
Twenty Years of Research on Cyclodextrin Conjugates with PAMAM Dendrimers
Pharmaceutics, 2021 Recently, the number of gene and oligonucleotide drugs are increasing. Of various drug delivery systems (DDSs) for gene and oligonucleotide drugs, few examples of the clinical application of polymer as drug carriers are known, despite development of the ...
Hidetoshi Arima
doaj +1 more source
Molecules, 2023 In the search for crop protectants, amino acid ester conjugates have been widely investigated as potential antifungal agents. In this study, a series of rhein–amino acid ester conjugates were designed and synthesized in good yields, and their structures ...
Shunshun Chen +8 more
doaj +1 more source
Novel G‐CSF conjugated anionic globular dendrimer: Preparation and biological activity assessment
Pharmacology Research & Perspectives, 2021 The most crucial role of granulocyte colony‐stimulating factor (G‐CSF) in the body is to increase the strength of immune system. In recent years, research on the use of nanoparticles in pharmaceuticals has been considered, most of which have been for ...
Seyed Shahaboddin Mousavi Motlagh +7 more
doaj +1 more source
Molecules, 2022 Oligonucleotides with an amino linker at the 3′-end are useful for the preparation of conjugated oligonucleotides. However, chemically modified nucleosides, which are unstable under basic conditions, cannot be incorporated into oligonucleotides using the
Takashi Osawa, Qin Ren, Satoshi Obika
doaj +1 more source
Drug Delivery, 2023 Most chemotherapeutic agents are nonspecific distribution and cause systemic toxicities. Polysaccharide-based conjugates are promising strategies to overcome these drawbacks.
Peng Dong +8 more
doaj +1 more source