Results 91 to 100 of about 1,475,137 (360)
Solid Phase Synthesis of a Metronidazole Oligonucleotide Conjugate
Molecules, 2006 Direct, solid phase synthesis of an oligonucleotide conjugate of the antibioticdrug metronidazole was accomplished by the phosphoramidite method. Removal ofprotecting groups and cleavage from the controlled pore glass (CPG) solid support wassuccessful ...
William Fraser +2 more
doaj +1 more source
Nonlinear conjugate gradients algorithm for 2-D magnetotelluric inversion
, 2001 We investigate a new algorithm for computing regularized solutions of the 2-D magnetotelluric inverse problem. The algorithm employs a nonlinear conjugate gradients (NLCG) scheme to minimize an objective function that penalizes data residuals and second ...
W. Rodi, R. Mackie
semanticscholar +1 more source
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Anticancer nanoparticulate polymer‐drug conjugate
Bioengineering & Translational Medicine, 2016 We review recent progress in polymer‐drug conjugate for cancer nanomedicine. Polymer‐drug conjugates, including the nanoparticle prepared from these conjugates, are designed to release drug in tumor tissues or cells in order to improve drugs’ therapeutic
Quanyou Feng, R. Tong
semanticscholar +1 more source
FEBS Letters, EarlyView.Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt +4 more
wiley +1 more source
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source
Reproduction by Conjugation [PDF]
Nature, 1877 IN Prof. Allen Thomson's Inaugural Address to the British Association, I find the following sentence, referring to the simplest form of sexual reproduction among cryptogams, known as conjugation:—“In more ordinary cases, as in Spirogyra, where the embryo is formed in one of the two cells, it seems to be indifferent in which of them it is formed.” If my
openaire +6 more sources
Porphyrin as Diagnostic and Therapeutic Agent
Molecules, 2019 The synthesis and application of porphyrins has seen a huge shift towards research in porphyrin bio-molecular based systems in the past decade. The preferential localization of porphyrins in tumors, as well as their ability to generate reactive singlet ...
Ncediwe Tsolekile +2 more
doaj +1 more source
Strategies and Advancement in Antibody-Drug Conjugate Optimization for Targeted Cancer Therapeutics
Biomolecules & Therapeutics, 2015 Antibody-drug conjugates utilize the antibody as a delivery vehicle for highly potent cytotoxic molecules with specificity for tumor-associated antigens for cancer therapy.
Eunhee Kim, Kristine M Kim
semanticscholar +1 more source