Results 91 to 100 of about 404,179 (310)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Moving force identification based on modified preconditioned conjugate gradient method [PDF]

, 2018
This paper develops a modified preconditioned conjugate gradient (M-PCG) method for moving force identification (MFI) by improving the conjugate gradient (CG) and preconditioned conjugate gradient (PCG) methods with a modified Gram-Schmidt algorithm. The
Zhen Chen, Chen, Zhen, Nguyen, Andy, Andy Nguyen, Chan, Tommy H. T., Tommy H.T. Chan   +5 more
core   +1 more source

Design, synthesis, and evaluation of antitumor activity of five natural product conjugates

Open Chemistry
Quercetin, jatrorrhizine, berberine, dehydrocostus lactone, and magnolol are prominent compounds known for their antitumor properties. A series of chemical reactions such as protection, hydrolysis, Michael addition and substitution were conducted using ...
Jiang Xiaofei, Zheng Shan, Jiang Yangming, YingYang, Li Qing, Wang Daoping   +5 more
doaj   +1 more source

SYNTHETIC CONJUGATED ANALOGUES OF CAPSULE POLYSACCHARIDES OF PNEUMOCOCCUS - AN INSTRUMENT FOR DETECTION OF POST-VACCINATION ANTIBODIES

Журнал микробиологии, эпидемиологии и иммунобиологии, 2016
Aim. Evaluation of the ability of capsule polysaccharides (CP) of Streptococcus pneumoniae serotype 3 and 14 and their synthetic structure analogues, conjugated with bovine serum albumin (BSA), to detect antibodies in post-vaccination sera of mice ...
E. A. Kurbatova, E. A. Akhmatova, N. K. Akhmatova, N. B. Egorova, N. E. Yastrebova, E. V. Sukhova, Yu. E. Tsvetkov, D. V. Yashunsky, N. E. Nifantiev   +8 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

A longitudinal household study of Streptococcus pneumoniae nasopharyngeal carriage in a UK setting. [PDF]

, 2005
A 10-month longitudinal household study of pre-school children and their families was undertaken with monthly visits collecting epidemiological data and nasopharyngeal swabs in Hertfordshire, England from 2001 to 2002.
Martin, SA, Edmunds, WJ, Hussain, M, George, R, Efstratiou, A, Miller, E, Pebody, RG, Melegaro, A, Talukdar, R   +8 more
core   +1 more source

Long term impact of conjugate vaccines on haemophilus influenzae meningitis: Narrative review

, 2021
H. influenzae serotype b (Hib) used to be the commonest cause of bacterial meningitis in young children. The widespread use of Hib conjugate vaccine has profoundly altered the epidemiology of H. influenzae meningitis.
Slack, MPE
core   +1 more source

Jasmonoyl-L-Tryptophan Disrupts IAA Activity through the AUX1 Auxin Permease

Frontiers in Plant Science, 2017
Amide-linked conjugates between tryptophan (Trp) and jasmonic (JA) or indole-3-acetic (IAA) acids interfered with gravitropism and other auxin-dependent activities in Arabidopsis, but the mechanism was unclear.
Paul Staswick, Martha Rowe, Edgar P. Spalding, Bessie L. Splitt   +3 more
doaj   +1 more source

Synthesis, conjugating capacity and biocompatibility evaluation of a novel amphiphilic polynorbornene

Designed Monomers and Polymers, 2020
Polynorbornenes, prepared by the ‘living’ and ‘controlled’ ring-opening metathesis polymerization (ROMP) method, have emerged as a stimuli-sensitive new class of polymer carriers.
Hengxi He, Bin Song, Guirong Qiu, Weixiang Wang, Haibin Gu   +4 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source