Results 101 to 110 of about 1,475,137 (360)

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

On the Conjugation of Amœba [PDF]

The Monthly Microscopical Journal, 1871
n ...
openaire   +3 more sources

CONJUGATIONS WITH GLUTATHIONE. THE ENZYMIC CONJUGATION OF SOME CHLOROCYCLOHEXENES [PDF]

Biochemical Journal, 1965
1. alpha-3,4,5,6-Tetrachlorocyclohex-1-ene and gamma-2,3,4,5,6-pentachlorocyclohex-1-ene are conjugated with glutathione in vitro by a rat-liver enzyme that is probably glutathione S-aryltransferase. 2. Chlorocyclohexane and the alpha-, beta-, gamma- and delta-isomers of hexachlorocyclohexane were not substrates for rat-liver glutathione S ...
P. Sims, P. L. Grover
openaire   +3 more sources

The regio-selective synthesis of 10-hydroxy camptothecin norcantharidin conjugates and their biological activity evaluation in vitro [PDF]

Royal Society Open Science, 2018
A series of conjugates of 10-hydroxy camptothecin (HCPT) with functionalized norcantharidin derivatives were regio-selectively synthesized in the condition of (3-dimethylaminopropyl) ethyl-carbodiimide monohydrochloride in a moderate yield.
Chang K. Zhao, Chan Li, Xian H. Wang, Yu J. Bao, Fu H. Yang, Mei Huang   +5 more
doaj   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Conjugation on reddening sequences and conjugation difference

Journal of Algebra
We describe the conjugation of the reddening sequence according to the formula of $c$-vectors with respect to changing the initial seed. As applications, we extend the Rotation Lemma, the Target before Source Theorem, and the mutation invariant property of the existence of reddening sequences to totally sign-skew-symmetric cluster algebras. Furthermore,
Siyang Liu, Jie Pan
openaire   +2 more sources

Serotype-Specific Changes in Invasive Pneumococcal Disease after Pneumococcal Conjugate Vaccine Introduction: A Pooled Analysis of Multiple Surveillance Sites

PLoS Medicine, 2013
In a pooled analysis of data collected from invasive pneumococcal disease surveillance databases, Daniel Feikin and colleagues examine serotype replacement after the introduction of 7-valent pneumococcal conjugate vaccine (PCV7) into national ...
D. Feikin, E. Kagucia, J. Loo, R. Link-Gelles, M. Puhan, T. Cherian, O. Levine, C. Whitney, K. O'Brien, M. Moore   +9 more
semanticscholar   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Geodesic connectedness and conjugate points in GRW spacetimes

, 2002
Given two points of a Generalized Robertson-Walker spacetime, the existence, multiplicity and causal character of geodesic connecting them is characterized. Conjugate points of such geodesics are related to conjugate points of geodesics on the fiber, and
Alías, Benci, Benci, Benci, Calabi, Giannoni, Giannoni, Giannoni, Helfer, José Luis Flores, Miguel Sánchez, Sánchez, Sánchez, Sánchez, Uhlenbeck   +14 more
core   +1 more source

Global Convergence Properties of Conjugate Gradient Methods for Optimization

SIAM Journal on Optimization, 1992
This paper explores the convergence of nonlinear conjugate gradient methods without restarts, and with practical line searches. The analysis covers two classes of methods that are globally convergent on smooth, nonconvex functions. Some properties of the
Jean Charles Gilbert, J. Nocedal
semanticscholar   +1 more source