Results 321 to 330 of about 1,475,137 (360)
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Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate.
Cancer Research, 2008HER2 is a validated target in breast cancer therapy. Two drugs are currently approved for HER2-positive breast cancer: trastuzumab (Herceptin), introduced in 1998, and lapatinib (Tykerb), in 2007.
Gail D Lewis Phillips +16 more
semanticscholar +1 more source
Journal of the American Chemical Society, 2014
All drugs for cancer therapy face several transportation barriers on their tortuous journey to the action sites. To overcome these barriers, an effective drug delivery system for cancer therapy is imperative.
Ping Huang +7 more
semanticscholar +1 more source
All drugs for cancer therapy face several transportation barriers on their tortuous journey to the action sites. To overcome these barriers, an effective drug delivery system for cancer therapy is imperative.
Ping Huang +7 more
semanticscholar +1 more source
Small conjugate-based theranostic agents: an encouraging approach for cancer therapy.
Chemical Society Reviews, 2015The advances in genomics, proteomics, and bioinformatics have directed the development of new anticancer agents to reduce drug abuse and increase safe and specific drug treatment.
R. Kumar +6 more
semanticscholar +1 more source
A New Conjugate Gradient Method with Guaranteed Descent and an Efficient Line Search
SIAM Journal on Optimization, 2005A new nonlinear conjugate gradient method and an associated implementation, based on an inexact line search, are proposed and analyzed. With exact line search, our method reduces to a nonlinear version of the Hestenes--Stiefel conjugate gradient scheme ...
W. Hager, Hongchao Zhang
semanticscholar +1 more source
Annals of the New York Academy of Sciences, 2013
There has been considerable effort expended in the investigation of the potential of siderophore conjugates of antibiotics to circumvent the permeability barrier imposed by the outer membrane of Gram‐negative bacteria. There is also a small group of natural conjugates, the sideromycins.
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There has been considerable effort expended in the investigation of the potential of siderophore conjugates of antibiotics to circumvent the permeability barrier imposed by the outer membrane of Gram‐negative bacteria. There is also a small group of natural conjugates, the sideromycins.
openaire +3 more sources
A Nonlinear Conjugate Gradient Method with a Strong Global Convergence Property
SIAM Journal on Optimization, 1999Conjugate gradient methods are widely used for unconstrained optimization, especially large scale problems. The strong Wolfe conditions are usually used in the analyses and implementations of conjugate gradient methods.
Yuhong Dai, Ya-xiang Yuan
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Microbiology, 2003
The review considers experimental data on the conjugal transfer of plasmids in the Bacillus cereus and Bacillus subtilis groups (the transfer of large self-transmissible plasmids and the mobilization of small plasmids). Conjugation in bacilli is compared with conjugation in E. coli dependent on the F factor.
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The review considers experimental data on the conjugal transfer of plasmids in the Bacillus cereus and Bacillus subtilis groups (the transfer of large self-transmissible plasmids and the mobilization of small plasmids). Conjugation in bacilli is compared with conjugation in E. coli dependent on the F factor.
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Preparation of Avidin Conjugates [PDF]
, 1996 The high-affinity avidin-biotin system has found applications in different fields of biotechnology, including immunoassays, histochemistry, affinity chromatography, and drug delivery, to name a few. A brief description of avidin and avidin-like molecules, streptavidin, deglycosylated avidin, and NeutraLite avidin is presented in the Chapter 2.
Mahesh K. Bhalgat, Rosaria P. Haugland
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A small-molecule drug conjugate for the treatment of carbonic anhydrase IX expressing tumors.
Angewandte Chemie, 2014Antibody-drug conjugates are a very promising class of new anticancer agents, but the use of small-molecule ligands for the targeted delivery of cytotoxic drugs into solid tumors is less well established.
N. Krall +5 more
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