Results 71 to 80 of about 259,011 (271)
AntibioticsThe synthesis and antiplasmodial evaluation of new hybrids combining the pharmacophore structures of artemisinin, ciprofloxacin or norfloxacin, and 7-chloroquinoline are reported in this study. The first step for all of the syntheses is the obtainment of
Georgia Vamvoukaki +6 more
doaj +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 Steroids are classes of natural products widely distributed in nature, which have been demonstrated to exhibit broad biological functions, and have also attracted increasing interest from bioorganic and pharmaceutical researches.
Shaoyong Ke +8 more
doaj +1 more source
Molecules, 2015 In order to improve the antitumor activity and water solubility of 10-hydroxycamptothecin (HCPT), a series of novel HCPT conjugates were designed and synthesized by conjugating polyethylene glycol (PEG) to the 10-hydroxyl group of HCPT via a valine ...
Na Guo +5 more
doaj +1 more source
Conjugate but non inner conjugate subfactors [PDF]
Proceedings of the American Mathematical Society, 1996 It is shown that for each r ∈ { 4 cos 2 ( π / n ) : n ≥ 3 } ∪ [ 4 , ∞ ) , r \in \{4\cos ^{2}(\pi /n): n \ge 3\} \cup [4, \infty ),
openaire +2 more sources
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
A Geometric View of Conjugate Priors [PDF]
arXiv, 2010 In Bayesian machine learning, conjugate priors are popular, mostly due to mathematical convenience. In this paper, we show that there are deeper reasons for choosing a conjugate prior. Specifically, we formulate the conjugate prior in the form of Bregman divergence and show that it is the inherent geometry of conjugate priors that makes them ...
arxiv
Automated Augmented Conjugate Inference for Non-conjugate Gaussian Process Models [PDF]
arXiv, 2020 We propose automated augmented conjugate inference, a new inference method for non-conjugate Gaussian processes (GP) models. Our method automatically constructs an auxiliary variable augmentation that renders the GP model conditionally conjugate. Building on the conjugate structure of the augmented model, we develop two inference methods. First, a fast
arxiv
The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum
FEBS Letters, EarlyView.In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti +3 more
wiley +1 more source
Oscillation of a second order half-linear difference equation and the discrete Hardy inequality
Electronic Journal of Qualitative Theory of Differential Equations, 2017 In local terms on finite and infinite intervals we obtain necessary and sufficient conditions for the conjugacy and disconjugacy of the following second order half-linear difference equation \begin{equation*} \Delta(\rho_i|\Delta y_i|^{p-2}\Delta y_i ...
Aigerim Kalybay +3 more
doaj +1 more source