Results 71 to 80 of about 1,051,691 (340)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Oscillation of a second order half-linear difference equation and the discrete Hardy inequality

Electronic Journal of Qualitative Theory of Differential Equations, 2017
In local terms on finite and infinite intervals we obtain necessary and sufficient conditions for the conjugacy and disconjugacy of the following second order half-linear difference equation \begin{equation*} \Delta(\rho_i|\Delta y_i|^{p-2}\Delta y_i ...
Aigerim Kalybay, Danagul Karatayeva, Ryskul. Oinarov, Ainur Temirkhanova   +3 more
doaj   +1 more source

Synthesis, conjugating capacity and biocompatibility evaluation of a novel amphiphilic polynorbornene

Designed Monomers and Polymers, 2020
Polynorbornenes, prepared by the ‘living’ and ‘controlled’ ring-opening metathesis polymerization (ROMP) method, have emerged as a stimuli-sensitive new class of polymer carriers.
Hengxi He, Bin Song, Guirong Qiu, Weixiang Wang, Haibin Gu   +4 more
doaj   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Synthesis and Biological Evaluation of Novel Water-Soluble Poly-(ethylene glycol)-10-hydroxycamptothecin Conjugates

Molecules, 2015
In order to improve the antitumor activity and water solubility of 10-hydroxycamptothecin (HCPT), a series of novel HCPT conjugates were designed and synthesized by conjugating polyethylene glycol (PEG) to the 10-hydroxyl group of HCPT via a valine ...
Na Guo, Du Jiang, Luyao Wang, Xing You, Yu-Ou Teng, Peng Yu   +5 more
doaj   +1 more source

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source

Jasmonoyl-L-Tryptophan Disrupts IAA Activity through the AUX1 Auxin Permease

Frontiers in Plant Science, 2017
Amide-linked conjugates between tryptophan (Trp) and jasmonic (JA) or indole-3-acetic (IAA) acids interfered with gravitropism and other auxin-dependent activities in Arabidopsis, but the mechanism was unclear.
Paul Staswick, Martha Rowe, Edgar P. Spalding, Bessie L. Splitt   +3 more
doaj   +1 more source

In vitro Production and Immunogenicity of a Clostridium Difficile Spore-Specific BclA3 Glycopeptide Conjugate Vaccine

Vaccines, 2020
: The BclA3 glycoprotein is a major component of the exosporangial layer of Clostridium difficile spores and in this study we demonstrate that this glycoprotein is a major spore surface associated antigen.
Annie Aubry, Wei Zou, Evguenii Vinogradov, Dean Williams, Wangxue Chen, Greg Harris, Hongyan Zhou, Melissa J. Schur, Michel Gilbert, Gillian R. Douce, Susan M. Logan   +10 more
doaj   +1 more source

Numerical studies of the simultaneous development of forced convective laminar flow with heat transfer inside a microtube at a uniform temperature

Open Engineering, 2022
Conjugate heat transfer is a complex problem because heat is transferred from a solid medium to a liquid medium through their interfaces. The steady-state laminar flow formed inside the microtubules is subjected to a constant temperature at the outer ...
Hamad Raisan F., Smaisim Ghassan F., Abed Azher M.   +2 more
doaj   +1 more source