Results 131 to 140 of about 100,362 (316)
Analysis of incomplete longitudinal binary responses with Bayesian method
Journal of Biostatistics and Epidemiology, 2015 Longitudinal study plays an important role in the epidemiological, clinical, and social science studies. In these kinds of studies, every individual is observed frequently during a period of time.
Habibollah Esmaily +4 more
doaj
Synthesis and evaluation of TEMPO probes and conjugates
, 2020 The site-specific introduction of a stable nitroxide spin label into biomolecules is known as site-directed spin labelling (SDSL). To date, no reports were done of utilizing multicomponent reactions (MCRs), in which the incorporation of the spin probe can be accomplished in a single step, providing an efficient route of spin-labelling.
openaire +2 more sources
, 2014 Targeted delivery of anticancer drugs to tumors has attracted considerable research interest because of its potential to reduce adverse toxicity while improving therapeutic efficacy. In this study, we synthesized and evaluated the therapeutic efficacy of
Kim, Hyungjun +9 more
core +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Incorporating external effects in economic evaluation: The case of smoking
, 2011 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The aim of this thesis is to explore methods to incorporate external effects on decision making of public health programmes in a UK setting, using smoking ...
Trapero-Bertran, Marta
core
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
The Development and Evaluation of Novel Reagents for Pre-Targeted Radioimmunotherapy
, 2004 PhDIn a pretargeting radioimmunotherapy system, monoclonal antibodies (MAbs) derivatised with a high affinity streptavidin receptor are used in a localisation step.
Hainsworth, James Edward Scott
core
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Учёные записки Казанского университета: Серия Естественные наукиThis study evaluates the antifibrotic properties of Xymedon, a pyrimidine derivative (1,2-dihydro-4,6-dimethyl-1-(2-hydroxyethyl)-pyrimidin-2-one), and its conjugate with L-ascorbic acid in a rat model of experimental liver fibrosis.
G. P. Belyaev +5 more
doaj +1 more source
Kernel Conjugate Gradient for Fast Kernel Machines
, 2018 We propose a novel variant of the conjugate gradi- ent algorithm, Kernel Conjugate Gradient (KCG), designed to speed up learning for kernel machines with differentiable loss functions. This approach leads to a better conditioned optimization problem
Nathan D. Ratliff (5398466) +1 more
core +1 more source