Results 121 to 130 of about 100,362 (316)

Molecular Umbrella Conjugate for the Ocular Delivery of siRNA

, 2015
The synthesis, computer modeling, and biological activity of an octawalled molecular umbrella short interfacing RNA (siRNA) conjugate is described. This molecular umbrella–siRNA conjugate exhibited mRNA knockdown activity in vitro in the absence of a ...
Lee Klein (1308357), Lynn A. O’Neill-Davis (1308360), Sandhya S. Nerurkar (1308333), Vasant Jadhav (1308330), Robert L. Peiffer (1308336), Vaclav Janout (1308342), Yu Yuan (1308366), David M. Tellers (1308345), Steven L. Regen (1308348), Lauren L. Cline (1308339), Tom Tucker (1308354), Ann O’Brien (1308363), Bradley P. Feuston (1308351)   +12 more
core   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Impacts of the 13-Valent Pneumococcal Conjugate Vaccine in Children

Journal of Immunology Research, 2015
Applications of the heptavalent pneumococcal conjugate vaccine (PCV7) in the pediatric immunization schedule have dramatically reduced the incidence of pneumococcal diseases in both vaccinated children and unvaccinated individuals of all ages.
Susanna Esposito, Nicola Principi
doaj   +1 more source

Conjugate-beam analogy for inflexed laminates

, 2020
A conjugate beam analogy is here proposed to evaluate the shear coupling in three-layered laminates formed by two external elastic plies bonded by a compliant interlayer.
Galuppi L., Royer-Carfagni G.
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Evaluation of the Effectiveness of Pneumococcal Conjugate Vaccines in Children

Journal of Education, Health and Sport
Diseases caused by Streptococcus pneumoniae are one of the most common infectious causes of death worldwide, making them a major global burden. For this reason, pneumococcal conjugate vaccines (PCVs) are one of the key achievements in preventive ...
Kinga Woźniak, Sandra Dachowska, Aleksandra Fałczyńska, Jan Haraj, Maria Namysł, Simon Matczak, Maciej Bieniek, Marcin Sobkowiak   +7 more
doaj   +1 more source

Evaluation of pharmacokinetics and pharmacodynamics of sinomenine-hyaluronic acid conjugate after intra-articular administration for osteoarthritis treatment

, 2019
Jie Liu,1,2,* Huarong Shao,1,* Shaoying Fang,1 Yanling Cheng,1 Peixue Ling,1,3 Jianying Chen1,3 1Key Laboratory of Biopharmaceuticals of Shandong Province, Shandong Academy of Pharmaceutical Sciences, Jinan, Shandong Province, China; 2Shandong ...
Liu J, Shao H, Chen J, Fang S, Ling P, Cheng Y   +5 more
core  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source