Results 101 to 110 of about 100,362 (316)

Are economic evaluations of vaccines useful to decision-makers? Case study of Haemophilus influenzae type b vaccines.

, 2004
BACKGROUND: In concert with efforts to increase global provision, economic evaluations of newer and relatively costly vaccines have proliferated in the medical literature.
Hill, Suzanne, Brinsmead, Regina, Walker, Damian   +2 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

In Vitro and In Vivo Evaluation of Cysteine and Site Specific Conjugated Herceptin Antibody-Drug Conjugates

PLoS ONE, 2014
Antibody drug conjugates (ADCs) are monoclonal antibodies designed to deliver a cytotoxic drug selectively to antigen expressing cells. Several components of an ADC including the selection of the antibody, the linker, the cytotoxic drug payload and the site of attachment used to attach the drug to the antibody are critical to the activity and ...
Dowdy Jackson, John Atkinson, Claudia I Guevara, Chunying Zhang, Vladimir Kery, Sung-Ju Moon, Cyrus Virata, Peng Yang, Christine Lowe, Jason Pinkstaff, Ho Cho, Nick Knudsen, Anthony Manibusan, Feng Tian, Ying Sun, Yingchun Lu, Aaron Sellers, Xiao-Chi Jia, Ingrid Joseph, Banmeet Anand, Kendall Morrison, Daniel S Pereira, David Stover   +22 more
openaire   +4 more sources

Analysis of fault networks and conjugate systems

, 2013
Faults networks exist over a range of scales and are important for understanding the brittle deformation and fluid transport processes within the Earth’s crust.
Nixon, Casey William
core  

Inversion of Eddy-Current Data via Conjugate Gradients

, 1990
In a companion paper, [1], we developed a rigorous, nonlinear model for inverting eddy-current data by means of the conjugate gradient algorithm. In this paper we will present some results obtained from the linearized version of the rigorous model.
Shamee, B., Jenkins, S., Sabbagh, H., S. Jenkins, Barkeshli, S., H. A. Sabbagh, D. J. Radecki, J. C. Treece, Treece, J.C., S. Barkeshli, Radecki, D., B. Shamee   +11 more
core   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Synthesis and characterization of physicochemical and immunological properties of recombinant NS3-G2 dendrimer conjugate

Vaccine Research, 2016
Introduction: An effective vaccine against HCV infection is not available. The non-structural protein 3 (NS3) of the virus as an important immunogenic candidate has been utilized in various modules.
F Javadi, P Rahimi, MH Modaressi, M Shafiee Ardestani, A Bolhassani, MR Aghasadeghi, SM Sadat   +6 more
doaj  

PSMA-targeted small-molecule docetaxel conjugate: Synthesis and preclinical evaluation

Prostate cancer is one of the most commonly diagnosed men's cancers and remains one of the leading causes of cancer death. The development of approaches to the treatment of this oncological disease is an ongoing process. In this work, we have carried out
Borisova Y.A., Majouga A.G., Ivanenkov Y.A., Gorelkin P.V., Vaneev A.N., Beloglazkina E.K., Erofeev A.S., Uspenskaya A.A., Khazanova E.S., Nimenko E.A., Shafikov R.R., Zyk N.Y., Ber A.P., Kolmogorov V.S., Kovalev S.V., Zyk N.V., Skvortsov D.A., Smirnova G.B., Khudyakov A.D., Petrov S.A., Machulkin A.E., Pokrovsky V.S.   +21 more
core   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source