Results 31 to 40 of about 66,000 (256)

A New Modified Conjugate Gradient for Nonlinear Minimization Problems

Science Journal of University of Zakho, 2022
The conjugate gradient is a highly effective technique to solve the unconstrained nonlinear minimization problems and it is one of the most well-known methods. It has a lot of applications.
Hussein Ageel Khatab, Salah G. Sharef
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

A Novel hybridization of CG-techniques for Solving Unconstrained Optimization Problems

Wasit Journal for Pure Sciences
Conjugate gradient methods are an extremely helpful way for handling large scale non-linear optimization issues. In this paper, based on the three famous Dai-yuan (DY), Liu–Storey (LS)and Conjugate-Descent (CD) conjugate gradient methods, a new hybrid ...
Hawraz Jabbar
doaj   +1 more source

The Limited Memory Conjugate Gradient Method [PDF]

SIAM Journal on Optimization, 2013
In theory, the successive gradients generated by the conjugate gradient method applied to a quadratic should be orthogonal. However, for some ill-conditioned problems, orthogonality is quickly lost due to rounding errors, and convergence is much slower than expected. A limited memory version of the nonlinear conjugate gradient method is developed.
William W. Hager, Hongchao Zhang
openaire   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The new spectral conjugate gradient method for large-scale unconstrained optimisation

Journal of Inequalities and Applications, 2020
The spectral conjugate gradient methods are very interesting and have been proved to be effective for strictly convex quadratic minimisation. In this paper, a new spectral conjugate gradient method is proposed to solve large-scale unconstrained ...
Li Wang, Mingyuan Cao, Funa Xing, Yueting Yang   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Two new spectral conjugate gradient algorithms based on Hestenes–Stiefel

Journal of Algorithms & Computational Technology, 2017
The spectral conjugate gradient algorithm, which is a variant of conjugate gradient method, is one of the effective methods for solving unconstrained optimization problems.
Guofang Wang, Rui Shan, Wei Huang, Wen Liu, Jingyi Zhao   +4 more
doaj   +1 more source