Results 51 to 60 of about 13,326,208 (288)
A New Modified Conjugate Gradient for Nonlinear Minimization Problems
Science Journal of University of Zakho, 2022 The conjugate gradient is a highly effective technique to solve the unconstrained nonlinear minimization problems and it is one of the most well-known methods. It has a lot of applications.
Hussein Ageel Khatab, Salah G. Sharef
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Global convergence of two spectral conjugate gradient methods [PDF]
, 2013 Two new nonlinear spectral conjugate gradient methods for solving unconstrained optimization problems are proposed. One is based on the Hestenes and Stiefel (HS) method and the spectral conjugate gradient method. The other is based on a mixed spectral HS-
Ahmad, Tahir +3 more
core +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
A numerical study of some hybrid conjugate gradient methods in optimal control
, 1995 The main work of this thesis is concerned with the comparison of conjugate gradient with hybrid conjugate gradient methods when they are applied to optimal control problems. Descriptions of the conjugate gradient.
Seyed A. Mohammadi (7158461)
core +3 more sources
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Conjugate gradient methods for continuation problems
, 1991 We study linear and nonlinear conjugate gradient methods for large sparse continuation problems. First we show how the linear conjugate gradient methods can be incorporated as linear solvers in the context of efficient high-order predictor-Newton ...
Georg, K. +3 more
core +1 more source
, 2008 Sparse signal approximations have become a fundamental tool in signal processing with wide ranging applications from source separation to signal acquisition.
Blumensath, T. +2 more
core +1 more source