Results 61 to 70 of about 12,602,940 (286)
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
The Limited Memory Conjugate Gradient Method [PDF]
SIAM Journal on Optimization, 2013 In theory, the successive gradients generated by the conjugate gradient method applied to a quadratic should be orthogonal. However, for some ill-conditioned problems, orthogonality is quickly lost due to rounding errors, and convergence is much slower than expected. A limited memory version of the nonlinear conjugate gradient method is developed.
William W. Hager, Hongchao Zhang
openaire +2 more sources
Impulse noise removal based on new hybrid conjugate gradient approach [PDF]
, 2016 summary:Image denoising is a fundamental problem in image processing operations. In this paper, we present a two-phase scheme for the impulse noise removal.
Kimiaei, Morteza, Rostami, Majid
core +1 more source
Several Guaranteed Descent Conjugate Gradient Methods for Unconstrained Optimization
Journal of Applied Mathematics, 2014 This paper investigates a general form of guaranteed descent conjugate gradient methods which satisfies the descent condition gkTdk≤-1-1/4θkgk2 θk>1/4 and which is strongly convergent whenever the weak Wolfe line search is fulfilled.
San-Yang Liu, Yuan-Yuan Huang
doaj +1 more source
Two Versions of the Spectral Nonlinear Conjugate Gradient Method
Al-Mustansiriyah Journal of Science, 2018 The nonlinear conjugate gradient method is widely used to solve unconstrained optimization problems. In this paper the development of different versions of nonlinear conjugate gradient methods with global convergence properties proved.
Basim A. Hassan, Haneen A. Alashoor
doaj +1 more source
Four–Term Conjugate Gradient (CG) Method Based on Pure Conjugacy Condition for Unconstrained Optimization [PDF]
Kirkuk Journal of Science, 2018 A four-term CG-method based on pure conjugacy condition are proposed, Research activities on extending three-term CG-method to the four-term conjugate gradient method.
Hisham. M. Azzam +2 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
, 2008 Sparse signal approximations have become a fundamental tool in signal processing with wide ranging applications from source separation to signal acquisition.
Blumensath, T. +2 more
core +1 more source