Results 61 to 70 of about 66,000 (256)
A New Hybrid Conjugate Gradient Method with Guaranteed Descent for Unconstraint Optimization
Al-Mustansiriyah Journal of Science, 2018 The conjugate gradient method an efficient technique for solving the unconstrained optimization problem. In this paper, we propose a new hybrid nonlinear conjugate gradient methods, which have the descent at every iteration and globally convergence ...
Basim A. Hassan
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
The conjugate gradient method with various viewpoints
CoRR, 2019 Connections of the conjugate gradient (CG) method with other methods in computational mathematics are surveyed, including the connections with the conjugate direction method, the subspace optimization method and the quasi-Newton method BFGS in numrical optimization, and the Lanczos method in numerical linear algebra.
Xuping Zhang, Jiefei Yang, Ziying Liu
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Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
TWO MODIFIED CONJUGATE GRADIENT METHODS AND THEIR APPLICATION TO IMAGE RESTORATION PROBLEMS
Ural Mathematical JournalConjugate gradient methods have significantly contributed to the discovery of minimizes of large-scale unconstrained optimization problems. In this paper, based on the Liu--Storey conjugate gradient method, two modified conjugate gradient methods (named ...
Abd Elhamid Mehamdia +3 more
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Iterated Ritz and conjugate gradient methods as solvers in constrained form-finding: A comparison. [PDF]
Heliyon, 2021 Šamec E, Gidak P, Fresl K.
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Enhancing Conjugate Gradient Method Through a Novel Investigation Parameter For Unconstrained Minimization [PDF]
مجلة التربية والعلمConjugate gradient algorithms come in a wide range of flavors. The conjugate gradient technique primarily concentrates on the spectral parameter. It follows the standard method proposed by Hastens and Stiefel, In this study, we have devised an innovative
Abd Hassan, Hamsa Saeed
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Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source