Results 41 to 50 of about 230,316 (281)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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Three Proposed Hybrid Genetic Algorithms [PDF]
Al-Rafidain Journal of Computer Sciences and Mathematics, 2013 Genetic Algorithm has been hybridized with classical optimization methods. Hybridization has been done in three approaches, by using conjugate gradient algorithm for Fletcher and Reeves, second by using steepest descent method and lastly by creation of ...
Ban Mitras, Nada Hassan
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Many-body effects and matrix inversion in low-Reynolds-number hydrodynamics [PDF]
, 2001 It is shown that the method of reflections in resistance form (with truncated multipoles) is one of many possible iterative methods to obtain the inverse of the mobility matrix (with the same truncation) in low-Reynolds-number hydrodynamics. Although the
Brady, John F., Ichiki, Kengo
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FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
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Conjugate gradient acceleration of iteratively re-weighted least squares methods
, 2016 Iteratively Re-weighted Least Squares (IRLS) is a method for solving minimization problems involving non-quadratic cost functions, perhaps non-convex and non-smooth, which however can be described as the infimum over a family of quadratic functions. This
Fornasier, Massimo +3 more
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
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The new spectral conjugate gradient method for large-scale unconstrained optimisation
Journal of Inequalities and Applications, 2020 The spectral conjugate gradient methods are very interesting and have been proved to be effective for strictly convex quadratic minimisation. In this paper, a new spectral conjugate gradient method is proposed to solve large-scale unconstrained ...
Li Wang +3 more
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A Bramble-Pasciak conjugate gradient method for discrete Stokes equations with random viscosity
, 2018 We study the iterative solution of linear systems of equations arising from stochastic Galerkin finite element discretizations of saddle point problems. We focus on the Stokes model with random data parametrized by uniformly distributed random variables ...
Lang, Jens +2 more
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A New Parameterized Conjugate Gradient Method based on Generalized Perry Conjugate Gradient Method
Tikrit Journal of Pure Science, 2023 A New Parameterized Conjugate Gradient Method based on Generalized Perry Conjugate Gradient Method is proposed to be based on Perry's idea, the descent condition and the global convergent is proven under Wolfe condition.
Khalil K. Abbo, Nazar K. Hussein
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source