Results 31 to 40 of about 25,443 (263)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Study on Heat Exchange Structure Design and Propulsion Performance of Solar Thermal Thruster

International Journal of Aerospace Engineering, 2022
This paper designed a platelet heat exchanger in the solar thermal thruster and analyzed the unsteady-state conjugate heat transfer characteristics between heat exchanger and propellant. The conjugate heat transfer (CHT) computational fluid dynamics (CFD)
Haoran Zhang, Minchao Huang, Xiaoping Hu
doaj   +1 more source

Topology Optimization of Turbulent Flow Cooling Structures Based on the k-ε Model

Entropy, 2023
Topology optimization (TO) is an effective approach to designing novel and efficient heat transfer devices. However, the TO of conjugate heat transfer has been essentially limited to laminar flow conditions only.
Yiwei Sun, Menglong Hao, Zexu Wang
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Simulation of Coupled Heat Transfer in Rotor/Stator Cavity of the Microturbine [PDF]

Problems of the Regional Energetics, 2019
The work is d to improving methods for calculating the cooling system of a microturbine with a rotor on air bearings. When designing gas turbines, it is important to integrate gas-dynamic calculations with thermal finite-element calculations. In practice,
Volkov K.N., Levihin A.A., Volobuev I.A., Melnikova A.I.   +3 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Numerical investigation of forced convection heat transfer from square cylinders in a channel covered by solid wall: Conjugate situation [PDF]

FME Transactions, 2017
Flow over two isothermal offset square cylinders in a confined channel is simulated for different Reynolds number to reveal the forced convection heat transfer from the heated square cylinders to the ambient fluid for the fixed blockage ratio.
Kanna Rajesh P., Sivasubramanian M., Uthayakumar M.   +2 more
doaj  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Numerical investigation of conjugate heat transfer in circular pipes considering wall thickness, material conductivity, and external convection

Results in Engineering
Conjugate heat transfer in circular pipes involves the coupled interaction of turbulent forced convection in the fluid, heat conduction through the pipe wall, and external convection to the ambient, which represents realistic conditions encountered in ...
Bekir Dogan
doaj   +1 more source