Results 51 to 60 of about 25,443 (263)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Numerical investigation of conjugate heat transfer in a partitioned cavity using NiO nanofluid and firefly algorithm

open access: yesEngineering Applications of Computational Fluid Mechanics
The fluid's heat transfer properties must be effectively utilized to create efficient heat exchangers. In various existing studies, the application of forced convection leads to pressure drops in conjugate heat transfer systems due to the nanoparticles ...
Anilkumar SH   +4 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

Conjugate heat transfer in wedged latticework cooling ducts with ejection flow for turbine blades

open access: yesCase Studies in Thermal Engineering
Trailing edge of high temperature turbine blades faces challenge of severe thermal environment due to wedged profile and hence limited cooling spaces.
Binye Yu, Xingwei Li, Jie Li, Shi Bu
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Numerical Simulation of Solar Radiation and Conjugate Heat Transfer through Cabin Seat Textile

open access: yesAUTEX Research Journal, 2020
The solar radiation and the conjugate heat transfer through the cabin seat fabric were investigated numerically with a focus on a comparative analysis of various fabric solar reflectance or reflectivity (SR) and inlet cooling air velocity.
Zhang Yijie, Jia Juhong
doaj   +1 more source

Modeling of Conjugate Heat Transfer [PDF]

open access: yesBulletin of the Faculty of Engineering. Mansoura University, 2020
Mohamed Elmarghany   +3 more
openaire   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

CONJUGATE HEAT TRANSFER COMPUTATIONS VIA LATTICE BOLTZMANN METHOD

open access: yesHavacılık ve Uzay Teknolojileri Dergisi, 2017
We developed a lattice Boltzmann Method code that is able to solve conjugate heat transfer problems on graphical processing unit. The solver uses Cartesian meshes of D2Q9 lattices and solves transient heat equation on both fluid and solid regions at once
Gregorio Gerardo Spinelli, Bayram Çelik
doaj  

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

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