Results 71 to 80 of about 116,530 (306)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Numerical investigation of conjugate heat transfer in a partitioned cavity using NiO nanofluid and firefly algorithm

Engineering Applications of Computational Fluid Mechanics
The fluid's heat transfer properties must be effectively utilized to create efficient heat exchangers. In various existing studies, the application of forced convection leads to pressure drops in conjugate heat transfer systems due to the nanoparticles ...
Anilkumar SH, Kousal C. Mohan, Arjun Premlal, Abhay S, Faiz Mohammed   +4 more
doaj   +1 more source

Numerical Simulation of Solar Radiation and Conjugate Heat Transfer through Cabin Seat Textile

AUTEX Research Journal, 2020
The solar radiation and the conjugate heat transfer through the cabin seat fabric were investigated numerically with a focus on a comparative analysis of various fabric solar reflectance or reflectivity (SR) and inlet cooling air velocity.
Zhang Yijie, Jia Juhong
doaj   +1 more source

Conjugate Heat Transfer Analysis in Cryogenic Microchannel Heat Exchanger [PDF]

, 2015
Printed circuit heat exchanger (PCHE) is a highly integrated plate type compact heat exchanger and most important as well as a most critical component in the cryogenic application. Compact heat exchangers are characterized by area density (? = AHT / V) i.
Biswal , Rasmikanti
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Design and optimization of a micro heat sink for concentrating photovoltaic/thermal (CPVT) systems [PDF]

, 2011
This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece.
3rd Micro and Nano Flows Conference (MNF2011), Belessiotis, V, Bergeles, GC, Karathanassis, IK, Papanicolaou, E   +4 more
core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

CONJUGATE HEAT TRANSFER COMPUTATIONS VIA LATTICE BOLTZMANN METHOD

Havacılık ve Uzay Teknolojileri Dergisi, 2017
We developed a lattice Boltzmann Method code that is able to solve conjugate heat transfer problems on graphical processing unit. The solver uses Cartesian meshes of D2Q9 lattices and solves transient heat equation on both fluid and solid regions at once
Gregorio Gerardo Spinelli, Bayram Çelik
doaj  

Conjugate heat transfer in wedged latticework cooling ducts with ejection flow for turbine blades

Case Studies in Thermal Engineering
Trailing edge of high temperature turbine blades faces challenge of severe thermal environment due to wedged profile and hence limited cooling spaces.
Binye Yu, Xingwei Li, Jie Li, Shi Bu
doaj   +1 more source