Results 71 to 80 of about 573,196 (348)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Conjugate Heat Transfer in Diverging Microchannels [PDF]
, 2015 A numerical study has been carried out to determine the effects of axial wall conduction during single-phase steady laminar flow of fluid through rectangular diverging (across the length of the channel) cross-sectional microchannel involving conjugate ...
Rajesh Kumar, V
core
Low-Concentration Solar-Power Systems Based on Organic Rankine Cycles for Distributed-Scale Applications: Overview and Further Developments [PDF]
, 2015 This paper is concerned with the emergence and development of low-to-medium-grade thermal-energy-conversion systems for distributed power generation based on thermo- dynamic vapor-phase heat-engine cycles undergone by organic working uids, namely ...
Markides, CN
core +2 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
CONJUGATE HEAT TRANSFER COMPUTATIONS VIA LATTICE BOLTZMANN METHOD
Havacılık ve Uzay Teknolojileri Dergisi, 2017 We developed a lattice Boltzmann Method code that is able to solve conjugate heat transfer problems on graphical processing unit. The solver uses Cartesian meshes of D2Q9 lattices and solves transient heat equation on both fluid and solid regions at once
Gregorio Gerardo Spinelli, Bayram Çelik
doaj
Conjugate heat transfer in wedged latticework cooling ducts with ejection flow for turbine blades
Case Studies in Thermal EngineeringTrailing edge of high temperature turbine blades faces challenge of severe thermal environment due to wedged profile and hence limited cooling spaces.
Binye Yu, Xingwei Li, Jie Li, Shi Bu
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Investigation of the forced convection heat transfer in the presence of radiation in metal foams using HPM [PDF]
مجله مدل سازی در مهندسی, 2016 Forced convection heat transfer in metal foams in the presence of radiation heat transfer is studied using the homotopy perturbation method (HPM). To see wall effects, Darcy-Brinkman model for the flow in porous media is used.
Maziar Dehghan +4 more
doaj +1 more source
Multiphysics Computational Analysis of a Solid-Core Nuclear Thermal Engine Thrust Chamber [PDF]
, 2007 The objective of this effort is to develop an efficient and accurate computational heat transfer methodology to predict thermal, fluid, and hydrogen environments for a hypothetical solid-core, nuclear thermal engine - the Small Engine.
Canabal, Francisco +3 more
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source