Results 81 to 90 of about 573,196 (348)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
The program FANS-3D (finite analytic numerical simulation 3-dimensional) and its applications [PDF]
In this study, the program named FANS-3D (Finite Analytic Numerical Simulation-3 Dimensional) is presented. FANS-3D was designed to solve problems of incompressible fluid flow and combined modes of heat transfer.
Bravo, Ramiro H., Chen, Ching-Jen
core +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
TASK Quarterly, 2008 A capillary pumped loop (CPL) is a two-phase thermal control device applied in cooling electronic devices. A two-dimensional conjugate numerical model of a miniature flat-plate capillary evaporator is presented in order to describe liquid and vapor flow,
ZHONGMIN WAN +3 more
doaj
Polyhedral meshing in numerical analysis of conjugate heat transfer
, 2018 Computational methods have been widely applied in conjugate heat transfer analysis. The very first and crucial step in such research is the meshing process which consists in dividing the analysed geometry into numerous small control volumes (cells).
M. Sosnowski +3 more
semanticscholar +1 more source
Conjugate Heat Transfer Analysis in Cryogenic Microchannel Heat Exchanger [PDF]
, 2015 Printed circuit heat exchanger (PCHE) is a highly integrated plate type compact heat exchanger and most important as well as a most critical component in the cryogenic application. Compact heat exchangers are characterized by area density (? = AHT / V) i.
Biswal , Rasmikanti
core
Linear irreversible heat engines based on the local equilibrium assumptions [PDF]
, 2015 We formulate an endoreversible finite-time Carnot cycle model based on the assumptions of local equilibrium and constant energy flux, where the efficiency and the power are expressed in terms of the thermodynamic variables of the working substance.
Izumida, Yuki, Okuda, Koji
core +2 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
FEBS Open Bio, EarlyView.The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan +6 more
wiley +1 more source
Immersing NURBS for CFD applications
, 2013 International audienceWe present a new immersed method for solving conjugate heat transfer and fluid-solid interactions (FSI). It is based on the use of Non Uniform Rational B-Splines (NURBS) to compute the distance function ans thus representing the ...
Coupez, Thierry +3 more
core +1 more source