Results 161 to 170 of about 2,663,278 (338)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

HIV Infection and the Epidemiology of Invasive Pneumococcal Disease (IPD) in South African Adults and Older Children Prior to the Introduction of a Pneumococcal Conjugate Vaccine (PCV)

, 2016
Susan Meiring, Cheryl Cohen, Vanessa Quan, Linda de Gouveia, Charles Feldman, Alan Karstaedt, Keith P. Klugman, Shabir A. Madhi, Helena Rabie, Charlotte Sriruttan, Anne von Gottberg, GERMS-SA   +11 more
openalex   +2 more sources

Patatin‐domain‐containing (phospho)lipases under control: Mammalian co‐regulators and pathogenic activation mechanisms

FEBS Open Bio, EarlyView.
Patatin domain‐containing (phospho)lipases are lipid‐hydrolyzing enzymes central to metabolism, membrane remodeling, and signaling. Their activity relies on precise co‐activation mechanisms involving protein–protein interactions and conformational rearrangements.
Noopur Dubey, Lina Riegler‐Berket, Monika Oberer   +2 more
wiley   +1 more source

A Bifunctional Antibody Conjugate for Marking the Location of DNA Binding Proteins on DNA Fibers. [PDF]

ACS Omega
Pokharel D, Shaik A, Gali H, Ling C, Bellani MA, Seidman MM.   +5 more
europepmc   +1 more source

Effects of Prior Polysaccharide Vaccination on Magnitude, Duration, and Quality of Immune Responses to and Safety Profile of a Meningococcal Serogroup C Tetanus Toxoid Conjugate Vaccination in Adults

, 2004
Jo Southern, Sarah Deane, Lindsey Ashton, Ray Borrow, David Goldblatt, Nick Andrews, Paul Balmer, Rhonwen Morris, J. Simon Kroll, Elizabeth Miller   +9 more
openalex   +1 more source

Pneumococcal carriage and antibiotic susceptibility patterns from two cross-sectional colonization surveys among children aged <5 years prior to the introduction of 10-valent pneumococcal conjugate vaccine — Kenya, 2009–2010 [PDF]

, 2017
Miwako Kobayashi, Laura Conklin, Godfrey Bigogo, Geofrey Jagero, Lee M. Hampton, Katherine E. Fleming-Dutra, Muthoni Junghae, Maria da Glória Carvalho, Fabiana Cristina Pimenta, Bernard Beall, Thomas H. Taylor, Kayla F. Laserson, John Vulule, Chris Van Beneden, Lindsay Kim, Daniel R. Feikin, Cynthia G. Whitney, Robert F. Breiman   +17 more
openalex   +1 more source

The empirical Bayes estimators of the variance parameter of the normal distribution with a conjugate inverse gamma prior under Stein’s loss function

, 2022
Ying‐Ying Zhang, Yuan-Yu Zhang, Zeyu Wang, Ya Sun, Ji Sun, Ya Sun, Ji Sun   +6 more
openalex   +2 more sources

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Comparative Efficacy and Safety of Antibody-Drug Conjugates Versus Standard Chemotherapy in Metastatic Breast Cancer: A Comprehensive Systematic Review and Meta-Analysis. [PDF]

Cureus
Teama H, Elnewishy A, Noureldin M, Elnewishy O.   +3 more
europepmc   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source