Results 41 to 50 of about 2,663,278 (338)

Trastuzumab deruxtecan: A quantum leap in HER2-positive breast cancer

Indian Journal of Medical and Paediatric Oncology, 2019
Docetaxel, trastuzumab, and pertuzumab, known as THP, is the preferred first-line treatment for HER2-positive advanced breast cancer, and the second-line drug of choice is trastuzumab emtansine.
Manikandan Dhanushkodi
doaj   +1 more source

An Efficient Gaussian Filter Based on Gaussian Symmetric Markov Random Field

IEEE Access, 2022
This article presents a new image denoising algorithm that uses Gaussian Symmetric Markov random fields based on maximum a posteriori estimation. First, an image denoising model based on Gaussian Symmetric Markov random fields is built, and the image ...
Fusong Xiong, Jian Zhang, Zhiqiang Zhang, Yun Ling   +3 more
doaj   +1 more source

Praluzatamab Ravtansine, a CD166-Targeting Antibody–Drug Conjugate, in Patients with Advanced Solid Tumors: An Open-Label Phase I/II Trial

Clinical Cancer Research, 2022
Purpose: Praluzatamab ravtansine (CX-2009) is a conditionally activated Probody drug conjugate (PDC) comprising an anti-CD166 mAb conjugated to DM4, with a protease-cleavable linker and a peptide mask that limits target engagement in normal tissue and ...
V. Boni, M. Fidler, H. Arkenau, A. Spira, F. Meric-Bernstam, N. Uboha, R. Sanborn, R. Sweis, P. Lorusso, M. Nagasaka, J. García-Corbacho, S. Jalal, J. Harding, Stella K. Kim, Iris H. C. Miedema, D. Vugts, M. Huisman, G. Zwezerijnen, G. V. van Dongen, C. W. Menke-van der Houven van Oordt, Song Wang, Tam Dang, Ivan A Zein, O. Vasiljeva, S. K. Lyman, V. Paton, A. Hannah, Joyce F. Liu   +27 more
semanticscholar   +1 more source

Bayes Estimation under Conjugate Prior for the Case of Power Function Distribution

, 2012
The Bayesian estimation approach is a non-classical device in the estimation part of statistical inference which is very useful in real world situation. The main objective of this paper is to study the Bayes estimators of the parameter of Power function ...
Habibur Rahman, M. Roy, A. R. Baizid
semanticscholar   +1 more source

Uptake of Pneumococcal Vaccines Among U.S. Adults After 2022 Update to Recommendations

AJPM Focus
Introduction: Updated recommendations for adult pneumococcal vaccination in the U.S. (publication date: January 27, 2022) incorporated 2 new vaccines (15- and 20-valent pneumococcal conjugate vaccines), removed 13-valent pneumococcal conjugate vaccine ...
Ahuva Averin, MPP, Jeffrey Vietri, PhD, Adriano Arguedas Mohs, MD, Sarah J. Willis, PhD, MPH, Alexander Lonshteyn, PhD, Derek Weycker, PhD   +5 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Bayesian Estimation of the Exponential Parameter under a Multiply Type-II Censoring Scheme

Austrian Journal of Statistics, 2016
This paper provides the estimation of the scale parameter of the exponential distribution under multiply type-II censoring. Using generalized non-informative prior and natural conjugate prior, Bayes estimator and approximate Bayes estimators of the scale
Umesh Singh, Anil Kumar
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Is a single dose of meningococcal serogroup C conjugate vaccine sufficient for protection? experience from the Netherlands

BMC Infectious Diseases, 2012
Background The first meningococcal serogroup C (MenC) conjugate vaccine was licensed in 1999 and introduced in the United Kingdom. Countries that have implemented the MenC vaccine since then in their national immunisation programmes use different ...
Kaaijk Patricia, van der Ende Arie, Berbers Guy, van den Dobbelsteen Germie PJM, Rots Nynke Y   +4 more
doaj   +1 more source