Results 111 to 120 of about 53,707 (310)

A Catalytic Osmium Redox Couple Collapses Cancer Redox Balance

Advanced Science, EarlyView.
A stable Os(III)/Os(IV) redox couple is developed to disrupt the tumor cell redox balance by concurrently catalyzing ROS generation and GSH depletion. Osmium‐treated cells exhibit multiple cell death pathways, including apoptosis, ferroptosis, and immunogenic cell death.
Wan‐Qiong Huang, Tao Huang, Yiming Hao, Gui‐Feng Huang, Yi‐Lang Yan, Xin Fang, Ying Chen, Xiao‐Long Wei, Wai‐Lun Man, Wen‐Xiu Ni   +9 more
wiley   +1 more source

Nueva generación de Vacunas Conjugadas Antimeningococica: Fundamentos y Posibilidades a escala Mundial

VacciMonitor, 2009
The serogroup distribution of Neisseria meningitidis strains implicated in invasive disease varies geographically and temporally. Monovalent serogroup C conjugate vaccines have successfully reduced serogroup C disease in countries where they are used ...
Jacqueline Miller, Jan Poolman, Dominique Boutriau   +2 more
doaj  

Analytical Characterization of Pneumococcal Vaccine Conjugates Using SEC-MALS Technique

Methods and Protocols
Background/Objectives: Infection from Streptococcus pneumoniae can lead to serious complications, such as meningitis and pneumonia, in children under 2 years of age, older adults, and immunocompromised populations. Conjugate vaccines against the pathogen
Chloe Wright, Gowri Chellappan, Abigail Mydland, Gowthami Jagruthi Penumaka, Geetha Karengil, Harshita Seth, Anup Datta, Subhash V. Kapre   +7 more
doaj   +1 more source

Quadrivalent meningococcal conjugate vaccines

Vaccine, 2009
Neisseria meningitidis is an important cause of bacterial meningitis and septicaemia with most disease caused by meningococci bearing serogroups A, B, C, Y and W-135 polysaccharides. Monovalent serogroup C conjugate vaccines have become established in the immunisation programmes in many countries and the first quadrivalent meningococcal vaccine ...
Pace, D, Pollard, A, Messonier, N
openaire   +4 more sources

Haemophilus influenzae type b reemergence after combination immunization

, 2006
An increase in Haemophilus influenzae type b (Hib) in British children has been linked to the widespread use of a diphtheria/tetanus/acellular pertussis combination vaccine (DTaP-Hib).
Mary P.E. Slack, Heath, PT, Diane Irving, Slack, MPE, Nik G. Johnson, Lee, YC ; https://orcid.org/, Irving, D, Sheldon, J, Gail F. Balfour, Joanna Sheldon, Johnson, NG, Ruggeberg, JU, Balfour, GF, Slack, MP, Y. Chen Lee, Heath, PI, Pollard, AJ, Jens U. Ruggeberg, Paul T. Heath, Pollard, Andrew, Andrew J. Pollard, Lee, YC, Liddy, H, Helen Liddy   +23 more
core   +1 more source

A randomised trial evaluating the safety and immunogenicity of the novel single oral dose typhoid vaccine M01ZH09 in healthy Vietnamese children. [PDF]

, 2010
BACKGROUND: The emergence of drug resistant typhoid fever is a major public health problem, especially in Asia. An oral single dose typhoid vaccine would have major advantages.
Schultsz, C, To, S.D., Vinh Chau Nguyen Van, Dolecek, C., Thi Diem Ha Tran, Dolecek, Christiane, Nguyen, V.M.H., Van Vinh Chau Nguyen, Upton Anthony, Nguyen, T.D., Thi Dung Nguyen, James P May, Marques, F, Nguyen, T.T., Schultsz, Constance, Glover, Clare, Upton, A., Nguyen, Thi Cam Binh, Stockwell, E, Hoang Nguyen Van Minh, Schultsz, C., Farrar, Jeremy, Upton, A, Glover, C., Van Minh Hoang Nguyen, Nguyen, Thanh Truong, Filipe Marques, Nguyen, TCB, James P. May, Pham Van Toi, James I. Campbell, Stockwell, E., Pham, Van Toi, Elaine Stockwell, Nga Tran Thi Thu, Ninh, TTV, Tran, T.D.H., May, James P, James I Campbell, To, Song Diep, Nguyen, T.C.B., Toi Pham Van, Tran, Thi Thu Nga, May, J.P., Tran, TTN, Budhram, R., Tran, T.T.N., Simmons, Cameron P, Van Toi Pham, Tran, N.B.C., Lam, W., Glover Clare, Campbell, J.I., Marques, F., Ha Tran Thi Diem, Bich Chau Tran Nguyen, Tran, TDH, Nguyen, VVC, Campbell, JI, Ninh Thi Thanh Van, To, SD, Schultsz Constance, Dougan, Gordon, Ninh, Tran, Lam, Winnie, Nguyen, V.V.C., Campbell James I., Farrar Jeremy, Dolecek, C, Upton, Anthony, Christiane Dolecek, Cameron P. Simmons, Simmons, Cameron, Stockwell, Elaine, Tran, Tinh Hien, Ninh, Thi Thanh Van, Nguyen Thi Cam Binh, Budhram, Ronald, Nguyen Thi Dung, Dung Nguyen Thi, Hien Tran Tinh, Cao, Thu Thuy, Van Ninh Thi Thanh, Cao, T.T., Simmons, Cameron P., Constance Schultsz, Tran, NBC, Tran Tinh Hien, Stockwell Elaine, Nguyen, Van Minh Hoang, Dolecek Christiane, Tran, TH, Lam Winnie, Campbell, James I, Nguyen, Van Vinh Chau, Tran Thi Diem Ha, Nguyen, Thi Dung, Winnie Lam, Gordon Dougan, May James P., Farrar, J, Nguyen Bich Chau Tran, Nguyen, TC, Nguyen, TD, Jeremy Farrar, Tran, TT, Cao Thu Thuy, Tinh Hien Tran, Thi Thanh Van Ninh, Budhram, R, Pham, V.T., Thu Thuy Cao, Simmons, C.P., Nguyen, TT, Glover, C, Tran, TD, Thuy Cao Thu, Ninh, TT, Simmons, CP, May, James P., Dougan, G., Ronald Budhram, Pham, V.M., Thi Cam Binh Nguyen, Pham, Van Minh, Lam, W, Thanh Truong Nguyen, Nguyen Van Minh Hoang, Farrar, J., Van Minh Pham, Tran, Nguyen Bich Chau, Thi Thu Nga Tran, Song Diep To, Nguyen Thanh Truong, Dougan Gordon, Pham Van Minh, Cao, TT, Clare Glover, Nguyen Van Vinh Chau, To Song Diep, Ninh, T.T.V., Tran, NB, Nguyen, MV, Budhram Ronald, Tran Nguyen Bich Chau, Marques, Filipe, Campbell, James I., Tran, Thi Diem Ha, Simmons Cameron P., Binh Nguyen Thi Cam, Tran, T.H., Cameron P Simmons, Pham, VM, Nguyen, VM, Tran Thi Thu Nga, Marques Filipe, Pham, VT, Nguyen, VV, Minh Pham Van, May, JP, Dougan, G, Anthony Upton, Truong Nguyen Thanh   +162 more
core   +1 more source

Mechanism‐Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy

Advanced Science, EarlyView.
MISPOP integrates ensemble learning with membrane‐active physicochemical priors to identify Dermaseptin‐S9, a natural oncolytic peptide that disrupts tumor membranes, triggers immunogenic cell death, and shows strong antitumor activity. The study illustrates a mechanism‐informed route from peptide sequence data to cancer immunotherapy leads.
Wen Zhang, Shengxin Lu, Guangyong Zheng, Shensuo Li, Hongyu Chen, Mei Hong, Xiangru Zhou, Ruotian Tang, Ye Wu, Weidong Zhang, Dong Lu, Xin Luan   +11 more
wiley   +1 more source

A Plug‐and‐Play Platform for Customizing Multivalent Degraders and Degrader‐Drug Conjugates

Advanced Science, EarlyView.
Membrane proteins remain challenging targets for conventional TPD approaches. Here, the authors develop UPTAB, a modular platform leveraging ultrahigh‐affinity orthogonal Im/CL protein pairs for lysosomal degradation of membrane proteins. Mono‐targeted (Type‐I), dual‐targeted (Type‐II), and tri‐targeted (Type‐III) UPTABs enable simultaneous degradation
Mengqing Zhao, Yan Deng, Jianjian Han, Yong Xie, Kai Bao, Lixin Ma, Lilong Liu, Wuxiang Mao   +7 more
wiley   +1 more source

One-month evaluation of safety and immunogenicity of a Vi-DT typhoid conjugate vaccine (Bio-TCV®) in Indonesian subjects 6 months to 45 years: A phase III randomized clinical trial

Vaccine: X
Background: Typhoid fever typically affects children and young adults and is a considerable cause of morbidity and mortality. Vaccination is the most effective preventive strategy to control typhoid fever in the short to medium term.
Bernie Endyarni Medise, I. Gusti Ayu Trisna Windiani, Dominicus Husada, Rini Sekartini, Hartono Gunardi, Angga Wirahmadi, Dwiyanti Puspitasari, Leny Kartina, I. Gusti Agung Ngurah Sugitha Adnyana, I. Gusti Lanang Sidiartha, I. Made Dwi Lingga Utama, I. Ketut Agus Somia, Iris Rengganis, Sukamto Koesnoe, Hindra Irawan Satari, Soedjatmiko Soedjatmiko, Sri Rezeki Hadinegoro, Ismoedijanto Ismoedijanto, Parwati Setiono Basuki, Gatot Soegiarto, Soetjiningsih Soetjiningsih, Rini Mulia Sari, Mita Puspita, Aria Kekalih, Sreshta Mukhi, Vianca Samara Andhary, Novilia Sjafri Bachtiar, Sushant Sahastrabuddhe   +27 more
doaj   +1 more source

A Three Component Synthetic Vaccine Containing a β-Mannan T-Cell Peptide Epitope and a β-Glucan Dendritic Cell Ligand

Molecules, 2018
Glycoconjugates prepared from the capsular polysaccharide of several pathogenic bacteria and carrier proteins, such as CRM 197 or tetanus toxoid, have been one of the most successful public health measures to be implemented in the last quarter century. A
David R. Bundle, Eugenia Paszkiewicz, Hassan R. H. Elsaidi, Satadru Sekhar Mandal, Susmita Sarkar   +4 more
doaj   +1 more source