Results 291 to 300 of about 1,279,521 (342)
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siRNA Conjugate Delivery Systems
Bioconjugate Chemistry, 2008Small interfering RNA (siRNA) has been chemically conjugated to a variety of bioactive molecules, lipids, polymers, peptides, and inorganic nanostructured materials to enhance their pharmacokinetic behavior, cellular uptake, target specificity, and safety. To efficiently deliver siRNAs to the target cells and tissues, many different siRNA bioconjugates
Jeong, JH Jeong, Ji Hoon +3 more
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Ozonolysis of conjugated systems—II
Tetrahedron, 1962Abstract Ozonolysis of Δ 1,4 -keto steroids gave products with partial and complete degradationof the cross-conjugated group. The structures of the isolated compounds were exclusively proven and in the case of prednisone acetate, were corroborated by tracer studies with 4-C 14 -prednisone acetate.
E. Caspi, W. Schmid, B. Taqui Khan
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The Journal of Biochemistry, 2005
ISG15 is a ubiquitin-like protein that is upregulated on treatment with interferon. ISG15 is considered to be covalently conjugated to cellular proteins through a sequential reaction similar to that of the ubiquitin conjugation system consisting of E1/E2/E3 enzymes: UBE1L and UbcH8 have been reported to function as E1 and E2 enzymes, respectively, for ...
Tomoharu, Takeuchi +4 more
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ISG15 is a ubiquitin-like protein that is upregulated on treatment with interferon. ISG15 is considered to be covalently conjugated to cellular proteins through a sequential reaction similar to that of the ubiquitin conjugation system consisting of E1/E2/E3 enzymes: UBE1L and UbcH8 have been reported to function as E1 and E2 enzymes, respectively, for ...
Tomoharu, Takeuchi +4 more
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The Ubiquitin-Conjugation System
Annual Review of Genetics, 1992The ubiquitin/proteasome system is believed to be the major nonlysosomal proteolytic system of eukaryotic cells. It is present in the cytosol and the nucleus but apparently absent from the lumen of membrane-enclosed organelles, i. e., the endoplasmic reticulum, the Golgi and vesicular system, mitochondria, chloroplasts, and peroxisomes (for reviews see
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Effective conjugation length of π-conjugated systems
Chemical Physics Letters, 2004Abstract The optical absorption of ordered and disordered π-conjugated molecules is described on the same microscopic footing. This gives a concise picture of the length dependence of the optical absorption of π-conjugated systems.
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Hardy Spaces of Conjugate Systems of Temperatures
Canadian Journal of Mathematics, 1998AbstractWe define Hardy spaces of conjugate systems of temperature functions on ℝn+1+ . We show that their boundary distributions are the same as the boundary distributions of the usual Hardy spaces of conjugate systems of harmonic functions.
Guzmán-Partida, Martha +1 more
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The Tcp conjugation system of Clostridium perfringens
Plasmid, 2017The Gram-positive pathogen Clostridium perfringens possesses a family of large conjugative plasmids that is typified by the tetracycline resistance plasmid pCW3. Since these plasmids may carry antibiotic resistance genes or genes encoding extracellular or sporulation-associated toxins, the conjugative transfer of these plasmids appears to be important ...
Jessica A. Wisniewski, Julian I. Rood
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A protein conjugation system essential for autophagy
Nature, 1998Autophagy is a process for the bulk degradation of proteins, in which cytoplasmic components of the cell are enclosed by double-membrane structures known as autophagosomes for delivery to lysosomes or vacuoles for degradation. This process is crucial for survival during starvation and cell differentiation.
Noboru Mizushima +8 more
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Clinical significance of the glutathione-conjugating system
Pharmacological Research Communications, 1983Glutathione displays important functions in living cells of many species, human included. Apart from its direct antioxidative activity, which supports the maintenance of the reduced state of proteinthiols, and its possible role in amino acid transport across membranes, it appears to exert several detoxification functions.
C P, Siegers, M, Younes
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?, ? Conjugation in organometallic systems
Bulletin of the Academy of Sciences of the USSR Division of Chemical Science, 1979In concluding it should be noted that the data presented in the present work support the results of earlier chemical studies [1, 2, 7], insofar as they show that conjugation of the C-Hg bond with C=O and C=C bonds is realized in the mercury derivatives of the acyclic and monocyclic ketones and aldehydes, and their ally 1-type analogs.
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