Results 91 to 100 of about 163,659 (277)

High-throughput, quantitative analyses of genetic interactions in E. coli. [PDF]

, 2008
Large-scale genetic interaction studies provide the basis for defining gene function and pathway architecture. Recent advances in the ability to generate double mutants en masse in Saccharomyces cerevisiae have dramatically accelerated the acquisition of
A Roguev, AB Byrne, AE Rizzitello, AH Tong, AH Tong, Athanasios Typas, Barry L Wanner, Bentley Lim, BJ Bachmann, BJ Breitkreutz, BR Bochner, C Boone, C Onufryk, Carol A Gross, CS Chen, Deborah A Siegele, E Cascales, E Cascales, ES Charlson, G Butland, Hannes Braberg, Hirotada Mori, HJ Nielsen, HJ Nielsen, HS Girgis, J Pogliano, J Qu, JC Bardwell, JG Sklar, Jonathan S Weissman, K Ara, KB Low, LI Leichert, LM Parsons, M Ito, M Schuldiner, MA Gerding, Michael Shales, Natsuko Yamamoto, Nevan J Krogan, P Mazurkiewicz, PE Rouviere, PN Danese, Rikiya Takeuchi, Robert J Nichols, Sean R Collins, SR Collins, SR Collins, T Baba, T Inoue, V Francois, WP Hoekstra, X Pan   +52 more
core   +1 more source

GENETICS OF CHEMICAL INDUCTION OF CONJUGATION IN PARAMECIUM AURELIA [PDF]

Genetics, 1974
ABSTRACT Certain stocks of P. aurelia, syngen 8, could not be induced to conjugate in a solution (KCl + acriflavine + calcium-poor conditions) which was effective in inducing conjugation in other species of Paramecium as well as in other stocks of syngen 8.
openaire   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Artificial Conjugation in Escherichia coli and Transfer of Penicillinase Plasmid

پزشکی بالینی ابن سینا, 1999
Conjugation is a major mechanism of DNA transfer among bacteria which takes place in both laboratory and natural environment and brings about new characteristics. Extrachromosomal DNA called plasmid are important elements in this exchange.
Mohammad Javad Kajbaf, Mohammad Ali Mashhadizadeh, Heidar Reza Mohtadi   +2 more
doaj  

A Conditional Yeast E1 Mutant Blocks the Ubiquitin–Proteasome Pathway and Reveals a Role for Ubiquitin Conjugates in Targeting Rad23 to the Proteasome [PDF]

, 2007
E1 ubiquitin activating enzyme catalyzes the initial step in all ubiquitin-dependent processes. We report the isolation of uba1-204, a temperature-sensitive allele of the essential Saccharomyces cerevisiae E1 gene, UBA1.
Amerik A. Y., Babbitt S. E., Bertolaet B. L., Bertolaet B. L., Biggins S., Chen L., Cheng I. H., Ciechanover A., Deshaies R. J., Deveraux Q., Elsasser S., Elsasser S., Elsasser S., Finley D., Funakoshi M., Gandre S., Glickman M. H., Guthrie C., Haas A. L., Haracska L., Hicke L., Hofmann K., Johnson E. S., Kang Y., Kleijnen M. F., Kulka R. G., Lambertson D., Lambertson D., Lowe E. D., Madura K., McGrath J. P., Nazli Ghaboosi, Ortolan T. G., Peng J., Pickart C. M., Raasi S., Raasi S., Rao H., Raymond J. Deshaies, Richly H., Ryu K. S., Saeki Y., Saeki Y., Saeki Y., Salvat C., Schauber C., Schuberth C., Shimada K., Swanson R., Swanson R., van Nocker S., van Nocker S., Verma R., Verma R., Verma R., Walters K. J., Walters K. J., Watkins J. F., Wilkinson C.R.M., William Tansey   +59 more
core   +2 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Potentially harmful advantage to athletes: a putative connection between UGT2B17 gene deletion polymorphism and renal disorders with prolonged use of anabolic androgenic steroids [PDF]

, 2010
: BACKGROUND AND OBJECTIVE: With prolonged use of anabolic androgenic steroids (AAS), occasional incidents of renal disorders have been observed. Independently, it has also been established that there are considerable inter-individual and inter-ethnic ...
Barker, James, Deshmukh, Nawed, Hussain, Iltaf, Naughton, Declan P, Petroczi, Andrea, Szekely, Andrea D   +5 more
core   +3 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Influence of the absorber dimensions on wavefront shaping based on volumetric optoacoustic feedback [PDF]

, 2015
The recently demonstrated control over light distribution through turbid media based on real-time three-dimensional optoacoustic feedback has offered promising prospects to interferometrically focus light within scattering objects.
Dean-Ben, X. L., Estrada, H., Ozbek, A., Razansky, D.   +3 more
core   +1 more source