Results 221 to 230 of about 163,659 (277)

Hydrochalcogenation Reactions with Noncanonical Amino Acids as a Route to Increase Bioconjugate Valency. [PDF]

ACS Omega
Boyt EL, Skeen TL, Dimaranan CR, London EM, Wang AS, Rothman SK, Dehring MG, Willard AC, Peairs EM, King EA, Young DD.   +10 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Identification of strong constitutive promoters in Burkholderia stagnalis TBRC 18363 for activating natural product production in Gram-negative bacteria. [PDF]

Appl Microbiol Biotechnol
Wongsombat C, Mhuantong W, Kongsee J, Pruksatrakul T, Srichomthong K, Charoenyingcharoen P, Uawisetwathana U, Yukphan P, Vichai V, Pistorius D, Buntin K, Aroonsri A.   +11 more
europepmc   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Structure of the conjugation surface exclusion protein TraT. [PDF]

Commun Biol
Chen N, Bukys A, Lundgren CAK, Deme JC, El Sayyed H, Kapanidis AN, Lea SM, Berks BC.   +7 more
europepmc   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Correction to "Genetic and pharmacologic enhancement of SUMO₂ conjugation prevents and reverses cognitive impairment and synaptotoxicity in a preclinical model of Alzheimer's disease". [PDF]

Alzheimers Dement
europepmc   +1 more source

Plasmid Genomic Dynamics and One Health: Drivers of Antibiotic Resistance and Pathogenicity. [PDF]

Pathogens
Domingues CPF, Rebelo JS, Dionisio F, Nogueira T.   +3 more
europepmc   +1 more source

Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin, Sang Bin Hong, Yong Woo Shin, Inpyeong Hwang, Jaeseong Oh, Jihyeon Choi, Narae Kim, Jangsup Moon, Keun‐Hwa Jung, Kyung‐Il Park, Ki‐Young Jung, Kon Chu, Sang Kun Lee   +12 more
wiley   +1 more source

Genomic evolution and stability of the mcr-1-harboring IncI2 plasmid in the presence and absence of colistin. [PDF]

BMC Genomics
Shen C, Wu M, Su M, Wu H, Chen Y, Gulimire M, Lan K, Zhao C, Zhang X, Luo L, Wen S, Zhou H, Pu J, Zeng J, Xu L, Zhang Z, Huang B, Jiang Y, Chen C.   +18 more
europepmc   +1 more source