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Genetically Engineered Epidermal Growth Factor Conjugate Crosses Cell Membrane
Applied Biochemistry and Biotechnology, 2012Epidermal growth factor (EGF) is a well-known pleiotropic growth factor in mammal, and has been attempted to be used in many different fields. However, the application of EGF is limited because of its poor cell permeation. In order to increase membrane permeation ability of EGF, a genetically modified recombinant EGF (GST-TAT-EGF) was prepared through ...
Baoquan, Zhao, Yanru, Guo, Ailing, Fu
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Genetic Evidence of Protein Transfer during Bacterial Conjugation
Plasmid, 1999DNA can be transferred from eubacteria to at least plants, fungi, and all other eubacteria by related, plasmid-mediated conjugation. Little is known about the biochemistry of intraspecies or interspecies DNA transfer. Even less is known about what other molecules may accompany the DNA, or the direct or inheritable effects on recipients of these escort ...
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[Genetic control of plasmid R6K conjugativity].
Genetika, 1982The regions determining conjugation ability of plasmid R6K were localized by means of deletion mutants obtained in vitro and in vivo and Tra- mutants induced by integration of transposons Tn5, Tn7 and Tn9 into different DNA sites of the conjugative deletion mutant pAS3.
E G, Abalakina +3 more
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On the mechanism of genetic transfer during conjugation ofEscherichia coli
Journal of Cellular Physiology, 1967It seems likely that the transfer of genetic material observed upon mating of male strains of Escherichia coli K12 is due to (or is at least concomitant with) a particular replication of the donor DNA. The detailed mechanism of genetic transfer is discussed in the light of different, recently published experimental results.
F, Cuzin, G, Buttin, F, Jacob
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Genetic Organization and Expression of Non-Conjugative Plasmids
1981Non-conjugative plasmids are plasmids that are not able to transfer themselves to other cells without the help of a conjugative system provided by the large, so-called conjugative plasmids. Non-conjugative plasmids are small plasmids. Their M.W. generally does not exceed 10 Megadaltons. Furthermore, they are multicopy plasmids; that means that they are
H. John, J. Nijkamp, Eduard Veltkamp
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Conjugation and genetic recombination of Escherichia coli in soil
Soil Biology and Biochemistry, 1972Abstract Conjugation in Escherichia coli appears to occur in sterile soil. The recombinants produced in soil from a fertile cross do not have the complete chromosome transferred from the donor to the recipient. Soils support the growth of auxotrophic strains of E. coli, but growth and conjugation were enhanced by addition of montmorillonite.
Sheila R. Weinberg, G. Stotzky
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Pfizer Licenses Seattle Genetics’ Antibody-Drug Conjugate Technology
PharmaDeals Review, 2011Pfizer has entered into a collaboration with Seattle Genetics to license the company’s antibody-drug conjugate (ADC) technology to develop antibodies against a single oncology target. Seattle Genetics will receive US$8 M upfront and over US$200 M in potential progress-based milestone payments, as well as royalties on worldwide net sales of any ...
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Substrate-Induced Conjugation of Bilirubin in Genetically Deficient Newborn Rats
Science, 1970Bilirubin appears to induce its own conjugation with glucuronide. Bilibrubin uridine diphosphate-glucuronyltransferase activity is relatively high at birth in heterozygous offspring of permanently jaundiced female rats. The postnatal development of the transferase is accelerated in hyperbilirubinemic heterozygotes.
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Auxin Conjugates in Arabidopsis: Identification, Formation and Genetic Analysis
1998Most of the IAA in plants is found not as the free acid, but conjugated to carbohydrates, amino acids or peptides, forms that are thought to be biologically inactive. These conjugates are hypothesized to play roles in IAA homeostasis via transport, protection from degradation, hydrolysis to release free hormone, and detoxification of non-physiological ...
Barratt, Natalie M +4 more
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Hybrid optimizer based on genetic algorithms and conjugate gradient
IEEE Antennas and Propagation Society International Symposium (IEEE Cat. No.02CH37313), 2003This communication presents a commercial software application for solving optimization problems. The program implements a hybrid optimizer based on genetic algorithms and the gradient method. The application has been developed for RYMSA Co., where it is been used for the optimization of several electromagnetic problems.
C.D. Bregon, E.F. del Rio
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