Results 61 to 70 of about 163,659 (277)
Detecting rare gene transfer events in bacterial populations
Frontiers in Microbiology, 2014 Horizontal gene transfer (HGT) enables bacteria to access, share, and recombine genetic variation, resulting in genetic diversity that cannot be obtained through mutational processes alone.
Kaare Magne Nielsen +6 more
doaj +1 more source
Integrating Horizontal Gene Transfer and Common Descent to Depict Evolution and Contrast It with ‘‘Common Design [PDF]
, 2010 Horizontal gene transfer (HGT) and common descent interact in space and time. Because events of HGT co-occur with phylogenetic evolution, it is difficult to depict evolutionary patterns graphically. Tree-like representations of life’s diversification are
Espinosa, Avelina +1 more
core +2 more sources
Genetically Directed Production of Recombinant, Isosteric and Nonhydrolysable Ubiquitin Conjugates [PDF]
ChemBioChem, 2016 AbstractWe describe the genetically directed incorporation of aminooxy functionality into recombinant proteins by using a mutant Methanosarcina barkeri pyrrolysyl‐tRNA synthetase/tRNACUA pair. This allows the general production of nonhydrolysable ubiquitin conjugates of recombinant origin by bioorthogonal oxime ligation.
Stanley, Mathew, Virdee, Satpal
openaire +3 more sources
Frontiers in Bioengineering and Biotechnology, 2016 Conjugation of episomal plasmids from bacteria to diatoms advances diatom genetic manipulation by simplifying transgene delivery and providing a stable and consistent gene expression platform. To reach its full potential, this nascent technology requires
Rachel E Diner +6 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background The Improving Population Outcomes for Renal Tumours of childhood (IMPORT) is a prospective clinical observational study capturing detailed demographic and outcome data on children and young people diagnosed with renal tumours in the United Kingdom and the Republic of Ireland.
Naomi Ssenyonga +56 more
wiley +1 more source
Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapyinduced leukemia [PDF]
, 2001 Glutathione S-transferases (GSTs) detoxify potentially mutagenic and toxic DNA-reactive electrophiles, including metabolites of several chemotherapeutic agents, some of which are suspected human carcinogens.
Allan, J.M. +9 more
core +4 more sources
Assembly and transfer of tripartite integrative and conjugative genetic elements [PDF]
Proceedings of the National Academy of Sciences, 2016 Significance Integrative and conjugative elements (ICEs) are one of the most prevalent but least-characterized families of mobile genetic elements in bacteria. We identified a family of ICEs that exists as three separate parts integrated within the single chromosomes of symbiotic mesorhizobia.
Timothy L. Haskett +7 more
openaire +3 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background B‐acute lymphoblastic leukemia (B‐ALL) is the most common pediatric cancer, and while most children in high‐resource settings are cured, therapy carries risks for long‐term toxicities. Understanding parents’ concerns about these late effects is essential to guide anticipatory support and inform evolving therapeutic approaches ...
Kellee N. Parker +7 more
wiley +1 more source
The coevolution of toxin and antitoxin genes drives the dynamics of bacterial addiction complexes and intragenomic conflict [PDF]
, 2012 Bacterial genomes commonly contain ‘addiction’ gene complexes that code for both a toxin and a corresponding antitoxin. As long as both genes are expressed, cells carrying the complex can remain healthy.
Brown, Sam P. +3 more
core +1 more source
Using genetic algorithms to discover novel ground-state triplet conjugated polymers
Physical Chemistry Chemical Physics, 2022 A genetic algorithm rapidly finds new π-conjugated polymer candidates with ground-state triplet character through quantum chemical screening for small HOMO–LUMO gaps.
Omri D. Abarbanel, Geoffrey R. Hutchison
openaire +2 more sources