Results 181 to 190 of about 2,125,845 (252)

Aniridia‐associated keratopathy: Clinical and molecular mechanisms of disease progression and emerging therapeutic targets

Acta Ophthalmologica, Volume 104, Issue 6, Page 604-615, September 2026.
Abstract Congenital aniridia is a rare genetic disorder primarily caused by pathogenic variants of the PAX6 gene. It leads to various panocular anomalies, including aniridia‐associated keratopathy (AAK). This review highlights recent insights into its pathogenesis, focusing on clinical staging, microstructural changes in the cornea and molecular ...
N. Szentmáry, S. Suiwal, M. Amini, F. N. Fries, A. Náray, L. Latta, Z. Li, S. Li, S. Liu, S. L. Hsu, S. Kundu, G. Tóth, S. Trusen, J. Zimmermann, B. Seitz, B. Käsmann‐Kellner, Z. Hoxha, A. Langenbucher, O. Stachs, M. Cortón‐Perez, K. Tory, A. Csorba, Z. Z. Nagy, M. C. Acosta, J. Gallar, M. Csidey, E. Maka, T. Stachon   +27 more
wiley   +1 more source

Minocycline and bone marrow–derived mononuclear cells as potential therapeutics for hereditary retinal degenerations

Acta Ophthalmologica, Volume 104, Issue 6, Page e671-e685, September 2026.
Abstract Purpose To assess in Royal College of Surgeons (RCS) rats if the combination of two previously documented neuroprotective strategies: minocycline administration and bone marrow–derived mononuclear cells (BM‐MNCs) intravitreal transplantation, offers enhanced neuroprotection compared with each treatment alone.
Alba Videla‐Ristol, Ana Martínez‐Vacas, David García‐Bernal, Manuel Vidal‐Sanz, María Paz Villegas‐Pérez, Diego García‐Ayuso, Johnny Di Pierdomenico   +6 more
wiley   +1 more source

Melioidosis in companion animals: Analysis of 45 Australian cases (24 dogs; 21 cats) from 1997 to 2025 and a brief review of the animal and human literature

Australian Veterinary Journal, Volume 104, Issue 9, Page 563-580, September 2026.
Objective To report 45 cases of melioidosis in dogs and cats from northern Australia and analyse trends in epidemiology, clinical presentation, pathogenesis and response to treatment over a 27‐year period. Design Retrospective and prospective analysis of clinical records.
K Lee, C Shilton, S Benedict, M Krockenberger, M Mayo, BJ Currie, R Malik   +6 more
wiley   +1 more source

Processionary Moth Exposure in Europe: Toxic–Irritant and Immunoglobulin E‐Mediated Endotypes, Diagnosis and Management

Clinical &Experimental Allergy, Volume 56, Issue 9, Page 1017-1030, September 2026.
Most reactions are toxic–irritant, driven by epithelial injury and neuro‐inflammatory activation. IgE‐mediated allergy is less common but may cause immediate systemic reactions. Endotype differentiation guides diagnosis, risk stratification and management.
Prasad Dasari, Josefine Haas, Wolfgang Rohe, Kai Gloyna, Christoph Viebahn, Susann Forkel, Michael Szardenings, Christine Stadelmann, Michael P. Schön, Timo Buhl   +9 more
wiley   +1 more source

Determination of Human Effective Dose via Translational Ocular Modeling: Clinical Translation of a Novel Topical Agent Using PBPK

Clinical and Translational Science, Volume 19, Issue 9, September 2026.
Schematic workflow of the translational study. ABSTRACT Wet age‐related macular degeneration (wAMD) is a leading cause of vision loss, and human dose selection for ocular therapeutics remains a key translational challenge. We developed a physiologically based pharmacokinetic (PBPK) model for EB‐203 to guide dose selection by translating preclinical ...
Woojin Jung, Jamie Jaeheung Lee, Yunseok Cho, Kyoung Ah Min, Hwi‐yeol Yun, Soyoung Lee, Jaewook Yang, Jung‐woo Chae   +7 more
wiley   +1 more source

Neural modulation of ocular immunity: Exploring a sympathetic‐macrophage neuroimmune link in the human ciliary body

Journal of Anatomy, Volume 249, Issue 3, Page 565-577, September 2026.
Using microscopy and 3D confocal imaging on seven cadaveric eyes, we identified sympathetic nerves closely associated with β₂‐adrenergic receptor‐expressing macrophages in the human ciliary body (CB). These findings suggest a sympathetic‐macrophage neuroimmune link in the CB, potentially influencing ocular inflammation and degeneration, warranting ...
Tanya S. Karakyriakou, Claire Mackaaij, Mark van Zijverden, Hendrik A. Messal, Jeannette Ossewaarde‐van Norel, Ronald L. A. W. Bleys, Cindy G. J. Cleypool   +6 more
wiley   +1 more source

Bilateral Blepharoplasty and Shortening of the Third Eyelid Cartilage as Treatment for Chronic Corneal Ulceration in a Giant Rabbit—A Case Report

Veterinary Ophthalmology, Volume 29, Issue 5, September 2026.
ABSTRACT This case report describes the clinical presentation and successful surgical management of a combined dorsal entropion‐ectropion macroblepharon with an elongated and folded nictitating membrane in a 2‐year‐old male giant rabbit. The rabbit initially presented with bilateral chronic, recurrent corneal erosions secondary to abnormal eyelid and ...
Anja Suter, Angelie Shukla, Lara Scherer, Sandro Stalder, Antonella Rampazzo   +4 more
wiley   +1 more source

Limited Efficacy of Autologous Mesenchymal Stromal Cell Injections in Immunomodulatory‐Dependent Dogs With Aqueous Deficient Dry Eye Disease

Veterinary Ophthalmology, Volume 29, Issue 5, September 2026.
ABSTRACT Objective Aqueous deficient dry eye disease (ADDE) results from a quantitative reduction in aqueous tears. We sought to determine the clinical effect of autologous mesenchymal stromal cell (MSC) injections into the region of the lacrimal gland and the gland of the third eyelid in immunomodulatory‐dependent ADDE‐affected dogs. Methods Dogs (n = 
Brian C. Leonard, Shin Ae Park, Sun Young Kim, Kei Hayashi, Sara M. Thomasy, Vanessa Rozo, Monica J. Motta, Dori L. Borjesson, Christopher J. Murphy, Kathryn L. Good   +9 more
wiley   +1 more source

Sustained Tear Film Exposure After Parenteral Cefovecin Administration in Dogs: Pharmacokinetics and Relevance to Canine Bacterial Keratitis

Veterinary Ophthalmology, Volume 29, Issue 5, September 2026.
ABSTRACT Objective To characterize the tear film pharmacokinetics of parenterally administered cefovecin (Convenia) and compare tear concentrations with the minimum inhibitory concentrations (MICs) of common ocular pathogens. Animals Studied Six healthy research‐bred Beagles.
Meredith R. McClure, Lionel Sebbag, David J. Borts, Rachel A. Allbaugh, Jessica L. Payne, Melissa A. Kubai   +5 more
wiley   +1 more source

Complications Following Nictitating Membrane Resection in Horses: 92 Eyes (2015–2024)

Veterinary Ophthalmology, Volume 29, Issue 5, September 2026.
ABSTRACT Objective The goal of this retrospective study is to evaluate the complications following nictitating membrane resection in horses with the aim of providing valuable information on the risks of this surgical procedure. Animals 83 horses (92 eyes). Procedures Medical records for 83 horses that underwent nictitating membrane resection in 92 eyes
Tiantian Wu, Darko Stefanovski, Nicole M. Scherrer   +2 more
wiley   +1 more source