Results 91 to 100 of about 252,155 (281)

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Valency based domination number for Mycielskian of some graphs‎ [PDF]

Mathematics and Computational Sciences
Let G = (V, E) be a connected graph and γvb(G) denotes the valency based domination number of G or simply vb-domination number of G. In this paper, analogous to isolated vertex in domination, defined valency based isolated vertex (or simply, vb-isolated ...
Kavitha Thilakan, Karakkattu Subrahmanian Parvathy   +1 more
doaj   +1 more source

Connected Partitions via Connected Dominating Sets

The classical theorem due to Győri and Lovász states that any $k$-connected graph $G$ admits a partition into $k$ connected subgraphs, where each subgraph has a prescribed size and contains a prescribed vertex, as long as the total size of target subgraphs is equal to the size of $G$.
Niklanovits, Aikaterini, Simonov, Kirill, Verma, Shaily, Zeif, Ziena   +3 more
openaire   +3 more sources

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Connected k-Dominating Graphs

, 2017
For a graph G=(V,E), the k-dominating graph of G, denoted by $D_{k}(G)$, has vertices corresponding to the dominating sets of G having cardinality at most k, where two vertices of $D_{k}(G)$ are adjacent if and only if the dominating set corresponding to one of the vertices can be obtained from the dominating set corresponding to the second vertex by ...
Mynhardt, C. M., Roux, R., Teshima, L. E.   +2 more
openaire   +2 more sources

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Perfect connected-dominant graphs

Discussiones Mathematicae Graph Theory, 2003
If \(D\) is a dominating set in a graph \(G\) and \(G[D]\) is connected, then \(D\) is a connected dominating set. The minimum size of a connected dominating set in \(G\) is called the connected domination number of \(G\), denoted by \(\gamma_c(G)\). A graph \(G\) is a perfect connected-dominant graph if \(\gamma(H)= \gamma_c(H)\) for each connected ...
openaire   +2 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source