Results 51 to 60 of about 796,164 (288)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Design of shared steering control system with enhanced overall stability

Scientific Reports
The shared steering control (SSC) system is a solution for safe driving before achieving fully autonomous driving, however, its overall stability is easily affected by the driver characteristics.
Xueyun Li, Yiping Wang, Chuqi Su, Zhaoqing Wang, Xiaoyin Zheng, Jin Huang   +5 more
doaj   +1 more source

DCAN: Dynamic Channel Attention Network for Multi-Scale Distortion Correction

Sensors
Image distortion correction is a fundamental yet challenging task in image restoration, especially in scenarios with complex distortions and fine details.
Jianhua Zhang, Saijie Peng, Jingjing Liu, Aiying Guo   +3 more
doaj   +1 more source

Personnel emergency carrier vehicle [PDF]

, 1987
A personnel emergency carrier vehicle is disclosed which includes a vehicle frame supported on steerable front wheels and driven rear wheels. A supply of breathing air is connected to quick connect face mask coupling and umbilical cord couplings for ...
Fedor, Otto H., Owens, Lester J.
core   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Mass Platooning: Information Networking Structures for Long Platoons of Connected Vehicles

IEEE Open Journal of Intelligent Transportation Systems
Investigating Vehicle-to-everything (V2X) communication, we dive into the concept of vehicle platoons, a key innovation in transport systems, introducing a new era of cooperative driving.
Mahdi Razzaghpour, Babak Ebrahimi Soorchaei, Rodolfo Valiente, Yaser P. Fallah   +3 more
doaj   +1 more source

Space vehicle [PDF]

, 1975
A space vehicle having an improved ascent configuration for use in traveling in space is presented. Components of the vehicle are: (1) a winged orbiter having an elongater fuselage and rearwardly directed main engines fixed to the fuselage; (2) an ...
Vonpragenau, G. L.
core   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Device for coupling a first vehicle to a second vehicle [PDF]

, 1980
A device is disclosed, carried by a first vehicle such as an orbiting space shuttle, having a plurality of contact members for engaging and holding an annular ring on a second vehicle such as an orbiting payload.
Rudmann, A. A.
core   +1 more source

Simulation Framework for Cooperative Adaptive Cruise Control with Empirical DSRC Module

, 2018
Wireless communication plays a vital role in the promising performance of connected and automated vehicle (CAV) technology. This paper proposes a Vissim-based microscopic traffic simulation framework with an analytical dedicated short-range communication
Lee, Joyoung, Zhong, Zijia
core   +1 more source