Results 31 to 40 of about 797,477 (288)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Advancements in 3-D object detection: A comprehensive review
Journal of King Saud University: Computer and Information Sciences3-D object detection has become essential for autonomous systems, yet the field remains fragmented due to diverse sensor modalities, fusion strategies, and architectural designs.
Wenhuan Wu, Innocent Appiah, Rui Hu
doaj +1 more source
Zinc-oxygen primary cell yields high energy density [PDF]
, 1968 Zinc-oxygen primary cell yields high energy density for battery used as an auxiliary power source in space vehicle systems. Maximum reliability and minimum battery weight is achieved by using a stacking configuration of 23 series-connected modules with 6
Graff, C. B.
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
IET Image ProcessingThe fuzzy C‐means clustering (FCM) algorithm is widely used in greyscale and colour image segmentation, especially in real colour images. However, in the process of interested regions extraction, it performs barely satisfactory due to the use of single ...
Xie Zeyu +3 more
doaj +1 more source
Launch Vehicle Description [PDF]
, 1970 The Thorad-Agena is a two-stage launch vehicle consisting of a Thorad first-stage and an Agena second-stage, connected by a booster adapter. The composite vehicle, including the shroud and the booster adapter, is about 33 meters (109 ft) long.
Coffey, E. E., Geye, R. P.
core +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
IESSP: Information Extraction-Based Sparse Stripe Pruning Method for Deep Neural Networks
SensorsNetwork pruning is a deep learning model compression technique aimed at reducing model storage requirements and decreasing computational resource consumption.
Jingjing Liu +5 more
doaj +1 more source
Articulated suspension system [PDF]
, 1989 The invention provides a rough terrain vehicle which maintains a substantially constant weight, and therefore traction, on all wheels, despite one wheel moving considerably higher or lower than the others, while avoiding a very soft spring suspension ...
Bickler, Donald B.
core +1 more source