Results 41 to 50 of about 797,477 (288)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Personnel emergency carrier vehicle [PDF]

, 1987
A personnel emergency carrier vehicle is disclosed which includes a vehicle frame supported on steerable front wheels and driven rear wheels. A supply of breathing air is connected to quick connect face mask coupling and umbilical cord couplings for ...
Fedor, Otto H., Owens, Lester J.
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

SELF-ADAPTIVE AIR-PATH HEALTH MANAGEMENT FOR A HEAVY DUTY-DIESEL ENGINE

International Journal of Prognostics and Health Management, 2023
This paper presents the air-path health management strategy with the ability to estimate the mass-flows and mitigate (adapt to) the air-path faults in the exhaust system of a heavy-duty diesel combustion engine equipped with a twin-scroll turbine.
Tomáš Polóni, Paul Dickinson, Jianrui Zhang, Peng Zhou   +3 more
doaj   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Design of shared steering control system with enhanced overall stability

Scientific Reports
The shared steering control (SSC) system is a solution for safe driving before achieving fully autonomous driving, however, its overall stability is easily affected by the driver characteristics.
Xueyun Li, Yiping Wang, Chuqi Su, Zhaoqing Wang, Xiaoyin Zheng, Jin Huang   +5 more
doaj   +1 more source

DCAN: Dynamic Channel Attention Network for Multi-Scale Distortion Correction

Sensors
Image distortion correction is a fundamental yet challenging task in image restoration, especially in scenarios with complex distortions and fine details.
Jianhua Zhang, Saijie Peng, Jingjing Liu, Aiying Guo   +3 more
doaj   +1 more source

Research on vibration reduction performance of dynamic vibration absorber based on damping characteristic of a new material

Advances in Mechanical Engineering, 2020
The absorbing effect of traditional dynamic vibration absorber (TDVA) is satisfactory only when the natural frequency is close to the excitation frequency.
Weizhi Song, Zhien Liu, Chihua Lu, Yongchao Li, Bin Li   +4 more
doaj   +1 more source

Data sharing platform and security mechanism based on cloud computing under the Internet of Things

Open Computer Science, 2022
Under the background of the rapid development of information technology, people’s data and information security problems are becoming increasingly serious. Data and information can be leaked in daily Internet access or communications.
Cai Jie, Wang Jun
doaj   +1 more source