Results 61 to 70 of about 302,672 (265)

Research on high-cycle fatigue life of pontoon bridge connection joints using improved stress field intensity method

open access: yesFrontiers in Materials
Based on the fatigue life data of 30CrMnSiA steel and fatigue tests of pontoon bridge connecting joints, this study improves the stress field intensity approach.
Xiaolong Du   +7 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Investigation of wear mechanism of tread during operation of railway wheels [PDF]

open access: yesTransport Problems, 2012
Causes of wear particles formation on railway wheels tread were investigated. Structural factors connecting with plastic deformation, formation of “white layer”, and also with non-metallic inclusions and corrosive products of wheel steel, defining wear ...
Svetlana GUBENKO, Yuriy PROIDAK
doaj  

Parity results on connected ƒ-factors

open access: yesDiscrete Mathematics, 1986
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Structural design and motion response of parallelogram hydraulic support in pitching oblique mining face of steeply dipping coal seam

open access: yesMeitan kexue jishu
The hydraulic support is the core of the stability of the ‘surrounding rock and equipm ent’ system in the pitching oblique working face of steeply dipping coal seam.
Yongping WU   +7 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

PENGARUH INSTAGRAM TERHADAP KEPUTUSAN PEMBELIAN DI LUSI DAN PAKAN BY THE RIVER BALI

open access: yesJurnal IPTA
In this research, several factors will be discussed that can influence purchasing decisions at Lusi and Pakan by The River Bali, including content creation, content sharing, and connecting. The purpose of this study was to determine the effect of content
Nadia Marchya Ayu   +2 more
doaj   +1 more source

The microbiome in human skin aging

open access: yesFEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana   +3 more
wiley   +1 more source

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