Results 61 to 70 of about 1,357,146 (299)
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Shock and VibrationIn order to broaden the muffler frequency band in the low-frequency range of the exhaust muffler and to achieve the purpose of broadband noise reduction, in this paper, a model of an annular connecting pipe muffler is proposed using the finite element ...
Yue Cheng +4 more
doaj +1 more source
Indicators for managing human centred manufacturing [PDF]
, 2013 Establishing indicators for managing human factors (HF) aspects in the design of production systems remains a challenge. We address the problem in two dimensions – firstly, what aspects of HF are to be considered, and secondly, where in the development ...
Greig, Michael +3 more
core
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
To improve patients’ empowerment by selfconnection in home parenteral nutrition
Current Directions in Biomedical Engineering, 2021 One promising approach for patients who need parenteral nutrition to live an almost normal life, is to provide extra-hospital therapy. This therapy is supported by an ambulatory care service whose staff connects and disconnects the nutritional fluid day ...
Völz Diana +3 more
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Raumforschung und Raumordnung, 2012 Sustainable development, the great challenge of the twentyfirst century, requires a long-term economic use of valuable, increasingly scarce resources: land, materials, and energy.
Georg Schiller +2 more
doaj +1 more source
Characterising two-pathogen competition in spatially structured environments [PDF]
, 2014 Different pathogens spreading in the same host population often generate complex co-circulation dynamics because of the many possible interactions between the pathogens and the host immune system, the host life cycle, and the space structure of the ...
Colizza, Vittoria +5 more
core +4 more sources